TCP-1 ε Antibody (G-11): sc-515511

TCP-1 ε Antibody (G-11) is a mouse monoclonal IgG1 antibody that detects TCP-1 ε in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCP-1 ε is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. The CCT complex is composed of eight distinct subunits, each encoded by different genes, and TCP-1 ε plays a significant role in ensuring that these proteins achieve their functional conformations. TCP-1 ε functions extend beyond protein folding to cellular processes such as cytoskeletal organization and cellular signaling, which are vital for maintaining cellular integrity and function. Abnormalities in TCP-1 ε expression or function can lead to various diseases, including neurodegenerative disorders, highlighting the necessity of studying TCP-1 ε in both basic and clinical research. Anti-TCP-1 ε antibody (G-11) serves as an invaluable tool for researchers exploring the intricate roles of TCP-1 ε in cellular biology and disease mechanisms.

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TCP-1 ε Antibody (G-11) References:

1. Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease.  |  Yoo, BC., et al. 2001. Biochem Biophys Res Commun. 280: 249-58. PMID: 11162507
2. Differential expression of molecular chaperones in brain of patients with Down syndrome.  |  Yoo, BC., et al. 2001. Electrophoresis. 22: 1233-41. PMID: 11358150
3. Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia.  |  Bouhouche, A., et al. 2006. J Med Genet. 43: 441-3. PMID: 16399879
4. Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.  |  Sergeeva, OA., et al. 2013. J Biol Chem. 288: 17734-44. PMID: 23612981
5. Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy.  |  Sergeeva, OA., et al. 2014. J Biol Chem. 289: 27470-80. PMID: 25124038
6. Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.  |  Darrow, MC., et al. 2015. J Biol Chem. 290: 17451-61. PMID: 25995452
7. A Novel CCT5 Missense Variant Associated with Early Onset Motor Neuropathy.  |  Antona, V., et al. 2020. Int J Mol Sci. 21: PMID: 33076433
8. Roles of the miR-139-5p/CCT5 axis in hepatocellular carcinoma: a bioinformatic analysis.  |  Xu, J., et al. 2021. Int J Med Sci. 18: 3556-3564. PMID: 34522182
9. Muscle Histopathological Abnormalities in a Patient With a CCT5 Mutation Predicted to Affect the Apical Domain of the Chaperonin Subunit.  |  Scalia, F., et al. 2022. Front Mol Biosci. 9: 887336. PMID: 35720129
10. Histopathology of Skeletal Muscle in a Distal Motor Neuropathy Associated with a Mutant CCT5 Subunit: Clues for Future Developments to Improve Differential Diagnosis and Personalized Therapy.  |  Scalia, F., et al. 2023. Biology (Basel). 12: PMID: 37237456

The preferred TCP-1 ε antibody is TCP-1 ε Antibody (G-3): sc-376188.