Date published: 2025-10-2

1-800-457-3801

SCBT Portrait Logo
Seach Input

TC-O 9311 (CAS 444932-31-4)

0.0(0)
Write a reviewAsk a question

Alternate Names:
3,5-Dimethoxybenzoic acid 2-[(1-naphthalenylamino)carbonyl]hydrazide
Application:
TC-O 9311 is a potent agonist of GPR139
CAS Number:
444932-31-4
Molecular Weight:
365.38
Molecular Formula:
C20H19N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

TC-O 9311, also known as DMBNU, or 1-(3,5-Dimethoxybenzoyl)amino)-3-naphthalen-1-ylurea, is an activator of GPR139 as well as other proteins. Studies have revealed that TC-O 9311 has the ability to modulate various biological processes, leading to a wide range of activities, including anti-cancer, anti-inflammatory, and anti-microbial properties. Its versatility has prompted investigations into its potential as a treatment for neurological disorders such as Alzheimer′s disease and Parkinson′s disease. In vitro experiments have demonstrated the remarkable ability of TC-O 9311 to influence biological processes, notably its ability to inhibit the growth of cancer cells. It is hypothesized that this compound exerts its effects by binding to and activating specific receptors or enzymes. Notably, TC-O 9311 has been observed to bind to and activate cyclooxygenase-2 (COX-2), an enzyme involved in the production of inflammatory mediators. Furthermore, it has also been found to bind to and activate acetylcholinesterase (AChE), an enzyme responsible for the breakdown of the neurotransmitter acetylcholine, as well as GPR139. In conclusion, TC-O 9311 holds great potential in various scientifc fields due to its diverse biological activities, including anti-cancer, anti-inflammatory, and anti-microbial effects. While the precise mechanism of action requires further investigation, it is believed that TC-O 9311 modulates biological processes through receptor and enzyme interactions, notably with COX-2 AChE, and GRP139.


TC-O 9311 (CAS 444932-31-4) References

  1. Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.  |  Nepomuceno, D., et al. 2018. Front Pharmacol. 9: 157. PMID: 29599718
  2. Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors.  |  Wang, L., et al. 2019. Pharmacol Res Perspect. 7: e00466. PMID: 30774960
  3. GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.  |  Wang, L., et al. 2019. Front Neurosci. 13: 281. PMID: 30971885
  4. Effects of GPR139 agonism on effort expenditure for food reward in rodent models: Evidence for pro-motivational actions.  |  Münster, A., et al. 2022. Neuropharmacology. 213: 109078. PMID: 35561791

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

TC-O 9311, 10 mg

sc-362802
10 mg
$116.00

TC-O 9311, 50 mg

sc-362802A
50 mg
$620.00