TBX6 Antibody (1D11): sc-517027

TBX6 Antibody (1D11) is a mouse monoclonal IgG2a kappa light chain antibody that detects TBX6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TBX6 antibody (1D11) is available as non-conjugated format. TBX6 plays a crucial role in embryonic development, particularly in the formation and patterning of somites, which are precursors to the vertebral column and associated structures. Located in the primitive streak, tail bud, and presomitic mesoderm, TBX6 is essential for the specification of posterior paraxial mesoderm. Proper TBX6 function is vital, as absence leads to severe developmental defects, including replacement of posterior somites with ectopic neural tubes, highlighting importance in ensuring correct segmentation and organization of the developing embryo. Members of the T-box gene family, to which TBX6 belongs, are characterized by a conserved domain that facilitates DNA-binding and protein dimerization, underscoring evolutionary significance and involvement in various developmental processes across metazoans.

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TBX6 Antibody (1D11) References:

1. Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.  |  He, Ml., et al. 1999. Proc Natl Acad Sci U S A. 96: 10212-7. PMID: 10468588
2. Developmental regulation of Tbx5 in zebrafish embryogenesis.  |  Begemann, G. and Ingham, PW. 2000. Mech Dev. 90: 299-304. PMID: 10640716
3. tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish.  |  Ahn, DG., et al. 2000. Mech Dev. 95: 253-8. PMID: 10906473
4. Critical role for Tbx6 in mesoderm specification in the mouse embryo.  |  Chapman, DL., et al. 2003. Mech Dev. 120: 837-47. PMID: 12915233
5. Regulation of Tbx6 expression by Notch signaling.  |  White, PH., et al. 2005. Genesis. 42: 61-70. PMID: 15864811
6. Dll1 is a downstream target of Tbx6 in the paraxial mesoderm.  |  White, PH. and Chapman, DL. 2005. Genesis. 42: 193-202. PMID: 15986483
7. Cloning, mapping, and expression analysis of TBX15, a new member of the T-Box gene family.  |  Agulnik, SI., et al. 1998. Genomics. 51: 68-75. PMID: 9693034

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBX6 Antibody (1D11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TBX6 Antibody (1D11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBX6 Antibody (1D11) Specifications

Alternate Product Name: T-box transcription factor 6

Product Clone Name: 1D11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 191-299

Epitope Target: TBX6

Epitope Species: human

Product Reactivity/Detection: TBX6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TBX6 Antibody (1D11): N/A