TBX3 Antibody (A-6): sc-166623

TBX3 Antibody (A-6) is a mouse monoclonal IgM antibody that detects TBX3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TBX3 antibody (A-6) is available as the non-conjugated monoclonal isotype antibody. TBX3 plays a crucial role in developmental processes, particularly in the regulation of gene expression during embryonic development. TBX3 functions as a transcriptional repressor, which is essential for maintaining the balance of gene expression necessary for proper cellular differentiation and organogenesis. Dysregulation of TBX3 has been implicated in various human diseases, including ulnar-mammary syndrome and certain types of cancer, highlighting TBX3′s importance in both developmental biology and pathology. The T-box transcription factor family, to which TBX3 belongs, is characterized by a conserved DNA-binding domain that allows specific gene promoter interactions, thereby influencing the transcriptional landscape of developing tissues. Understanding TBX3′s functional mechanisms and protein interactions can provide insights into the molecular underpinnings of developmental disorders and cancer, making TBX3 (A-6) antibody a valuable tool for researchers studying these critical biological processes.

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TBX3 Antibody (A-6) References:

1. Zebrafish tbx-c functions during formation of midline structures.  |  Dheen, T., et al. 1999. Development. 126: 2703-13. PMID: 10331981
2. Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.  |  He, Ml., et al. 1999. Proc Natl Acad Sci U S A. 96: 10212-7. PMID: 10468588
3. Developmental regulation of Tbx5 in zebrafish embryogenesis.  |  Begemann, G. and Ingham, PW. 2000. Mech Dev. 90: 299-304. PMID: 10640716
4. tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish.  |  Ahn, DG., et al. 2000. Mech Dev. 95: 253-8. PMID: 10906473
5. The special stemness functions of Tbx3 in stem cells and cancer development.  |  Dong, L., et al. 2019. Semin Cancer Biol. 57: 105-110. PMID: 30268432
6. The roles and regulation of TBX3 in development and disease.  |  Khan, SF., et al. 2020. Gene. 726: 144223. PMID: 31669645
7. TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis.  |  Liang, B., et al. 2021. J Hepatol. 75: 120-131. PMID: 33577921
8. Efficient generation of TBX3+ atrioventricular conduction-like cardiomyocytes from human pluripotent stem cells.  |  Du, R., et al. 2023. Biochem Biophys Res Commun. 669: 143-149. PMID: 37271026
9. Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.  |  Zhang, Z., et al. 2024. Nat Commun. 15: 4108. PMID: 38750011
10. Overexpression of TBX3 suppresses tumorigenesis in experimental and human cholangiocarcinoma.  |  Deng, S., et al. 2024. Cell Death Dis. 15: 441. PMID: 38909034
11. Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family.  |  Law, DJ., et al. 1995. Mamm Genome. 6: 793-7. PMID: 8597636
12. Cloning, mapping, and expression analysis of TBX15, a new member of the T-Box gene family.  |  Agulnik, SI., et al. 1998. Genomics. 51: 68-75. PMID: 9693034

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBX3 Antibody (A-6) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-TBX3 Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBX3 Antibody (A-6) Specifications

Alternate Product Name: T-box transcription factor 3

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 320-411

Epitope Target: TBX3

Epitope Species: human

Product Reactivity/Detection: TBX3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for TBX3 Antibody (A-6): X: TransCruz Reagent