TBX2 Antibody (D-3): sc-514291

TBX2 Antibody (D-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects TBX2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TBX2 (D-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBX2 plays a crucial role in developmental processes, particularly in regulating gene expression during embryonic development. TBX2 is primarily located in the nucleus, where TBX2 functions as a transcription factor, binding to specific DNA sequences to modulate the expression of target genes involved in cell differentiation and organogenesis. Proper localization of TBX2 is essential for function, ensuring effective interaction with transcriptional machinery and other regulatory proteins to orchestrate complex gene expression programs necessary for development. Dysregulation of TBX2 has been implicated in various human diseases, including congenital malformations and certain cancers, highlighting TBX2′s importance in maintaining normal developmental processes and cellular functions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TBX2 Antibody (D-3) References:

1. Zebrafish tbx-c functions during formation of midline structures.  |  Dheen, T., et al. 1999. Development. 126: 2703-13. PMID: 10331981
2. Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.  |  He, Ml., et al. 1999. Proc Natl Acad Sci U S A. 96: 10212-7. PMID: 10468588
3. Developmental regulation of Tbx5 in zebrafish embryogenesis.  |  Begemann, G. and Ingham, PW. 2000. Mech Dev. 90: 299-304. PMID: 10640716
4. tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish.  |  Ahn, DG., et al. 2000. Mech Dev. 95: 253-8. PMID: 10906473
5. The role of Tbx2 and Tbx3 in mammary development and tumorigenesis.  |  Rowley, M., et al. 2004. J Mammary Gland Biol Neoplasia. 9: 109-18. PMID: 15300007
6. TBX2 and TBX3: the special value for anticancer drug targets.  |  Lu, J., et al. 2010. Biochim Biophys Acta. 1806: 268-74. PMID: 20624445
7. TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells.  |  Crawford, NT., et al. 2019. Oncogene. 38: 5971-5986. PMID: 31253870
8. TBX2 Drives Neuroendocrine Prostate Cancer through Exosome-Mediated Repression of miR-200c-3p.  |  Patel, GK., et al. 2021. Cancers (Basel). 13: PMID: 34638504
9. TBX2 controls a proproliferative gene expression program in melanoma.  |  Lu, S., et al. 2021. Genes Dev. 35: 1657-1677. PMID: 34819350
10. TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers.  |  McIntyre, AJ., et al. 2022. Nucleic Acids Res. 50: 6154-6173. PMID: 35687133
11. Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family.  |  Law, DJ., et al. 1995. Mamm Genome. 6: 793-7. PMID: 8597636
12. Cloning, mapping, and expression analysis of TBX15, a new member of the T-Box gene family.  |  Agulnik, SI., et al. 1998. Genomics. 51: 68-75. PMID: 9693034

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBX2 Antibody (D-3) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-TBX2 Antibody (D-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBX2 Antibody (D-3) Specifications

Alternate Product Name: T-box transcription factor 2

Product Clone Name: D-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 681-702

Epitope Target: TBX2

Epitope Species: human

Product Reactivity/Detection: TBX2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for TBX2 Antibody (D-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent