TBX18 Antibody (CD-21): sc-130428

TBX18 Antibody (CD-21) is a mouse monoclonal IgG2a kappa light chain antibody that detects TBX18 in mouse, rat, and human samples by western blotting (WB) and immunoprecipitation (IP). Anti-TBX18 antibody (CD-21) is available in a non-conjugated form, providing flexibility for various experimental needs. TBX18 plays a crucial role in regulating developmental processes, particularly in heart formation and urogenital system development. TBX18 is essential for proper mesodermal tissue differentiation and cardiac conduction system establishment. TBX18 helps orchestrate downstream target gene expression critical for embryonic development. Disruptions in TBX18 expression or function can lead to congenital heart defects and other developmental disorders, highlighting TBX18′s importance in both normal physiology and disease. The T-box transcription factor family, to which TBX18 belongs, is characterized by a conserved DNA-binding domain that allows these proteins to regulate gene expression during key developmental stages. Understanding TBX18′s role and interactions with other proteins can provide insights into molecular mechanisms underlying developmental biology and potential therapeutic targets for related diseases.

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TBX18 Antibody (CD-21) References:

1. Zebrafish tbx-c functions during formation of midline structures.  |  Dheen, T., et al. 1999. Development. 126: 2703-13. PMID: 10331981
2. Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.  |  He, Ml., et al. 1999. Proc Natl Acad Sci U S A. 96: 10212-7. PMID: 10468588
3. Developmental regulation of Tbx5 in zebrafish embryogenesis.  |  Begemann, G. and Ingham, PW. 2000. Mech Dev. 90: 299-304. PMID: 10640716
4. tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish.  |  Ahn, DG., et al. 2000. Mech Dev. 95: 253-8. PMID: 10906473
5. Hypoxia induced the differentiation of Tbx18-positive epicardial cells to CoSMCs.  |  Jing, X., et al. 2016. Sci Rep. 6: 30468. PMID: 27456656
6. Tbx18-positive cells-derived myofibroblasts contribute to renal interstitial fibrosis via transforming growth factor-β signaling.  |  Yuan, X., et al. 2021. Exp Cell Res. 405: 112682. PMID: 34118250
7. Tbx18 promoted the conversion of human-induced pluripotent stem cell-derived cardiomyocytes into sinoatrial node-like pacemaker cells.  |  Zhang, W., et al. 2022. Cell Biol Int. 46: 403-414. PMID: 34882885
8. Generation of a human embryonic stem cell line (WAe009-A-78) carrying homozygous TBX18 knockout.  |  Xu, Q., et al. 2022. Stem Cell Res. 62: 102804. PMID: 35533514
9. Tbx18 Orchestrates Cytostructural Transdifferentiation of Cardiomyocytes to Pacemaker Cells by Recruiting the Epithelial-Mesenchymal Transition Program.  |  Foster, DB., et al. 2022. J Proteome Res. 21: 2277-2292. PMID: 36006872
10. TBX18 knockdown sensitizes esophageal squamous cell carcinoma to radiotherapy by blocking the CHN1/RhoA axis.  |  Zhou, J., et al. 2023. Radiother Oncol. 186: 109788. PMID: 37399907
11. Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family.  |  Law, DJ., et al. 1995. Mamm Genome. 6: 793-7. PMID: 8597636
12. Cloning, mapping, and expression analysis of TBX15, a new member of the T-Box gene family.  |  Agulnik, SI., et al. 1998. Genomics. 51: 68-75. PMID: 9693034

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBX18 Antibody (CD-21) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TBX18 Antibody (CD-21) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBX18 Antibody (CD-21) Specifications

Alternate Product Name: T-box transcription factor 18

Product Clone Name: CD-21

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 454-560

Epitope Target: TBX18

Epitope Species: human

Product Reactivity/Detection: TBX18

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TBX18 Antibody (CD-21): N/A