TBRG4 Antibody (F-1): sc-373948

TBRG4 Antibody (F-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects TBRG4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TBRG4 (F-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBRG4, also known as transforming growth factor beta regulator 4, cell cycle progression restoration protein 2, or FASTKD4, is a 631 amino acid protein that features one RAP domain and is a member of the FAST kinase family. TBRG4 plays a crucial role in regulating cell cycle progression, which is vital for maintaining proper cellular function and preventing uncontrolled cell growth that can lead to cancer. TBRG4 is ubiquitously expressed across various tissues, and TBRG4 expression levels can influence cellular responses to growth factors and stress signals. The gene encoding TBRG4 is located on human chromosome 7p13, which is associated with several genetic disorders, including Osteogenesis imperfecta and Pendred syndrome. Notably, chromosome 7 has been implicated in various myeloid disorders, highlighting TBRG4′s importance in both normal physiology and disease states.

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TBRG4 Antibody (F-1) References:

1. The DNA sequence of human chromosome 7.  |  Hillier, LW., et al. 2003. Nature. 424: 157-64. PMID: 12853948
2. ATM activation by ionizing radiation requires BRCA1-associated BAAT1.  |  Aglipay, JA., et al. 2006. J Biol Chem. 281: 9710-8. PMID: 16452482
3. The neurobiology of Williams syndrome: cascading influences of visual system impairment?  |  Eckert, MA., et al. 2006. Cell Mol Life Sci. 63: 1867-75. PMID: 16810457
4. Shwachman-Diamond syndrome.  |  Shimamura, A. 2006. Semin Hematol. 43: 178-88. PMID: 16822460
5. Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization.  |  Osborne, LR., et al. 2006. Methods Mol Med. 126: 113-28. PMID: 16930009
6. Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more.  |  Reiner, O., et al. 2006. Neuromolecular Med. 8: 547-65. PMID: 17028375
7. Structural aberrations of chromosome 7 revealed by a combination of molecular cytogenetic techniques in myeloid malignancies.  |  Brezinová, J., et al. 2007. Cancer Genet Cytogenet. 173: 10-6. PMID: 17284364
8. Epigenetic modifications and chromatin loop organization explain the different expression profiles of the Tbrg4, WAP and Ramp3 genes.  |  Montazer-Torbati, MB., et al. 2008. Exp Cell Res. 314: 975-87. PMID: 18255060
9. Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta.  |  Tsipouras, P., et al. 1983. J Clin Invest. 72: 1262-7. PMID: 6313757
10. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci.  |  Liang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 3781-5. PMID: 9520444

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBRG4 Antibody (F-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TBRG4 Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBRG4 Antibody (F-1) Specifications

Alternate Product Name: TBRG4

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 370-631

Epitope Target: TBRG4

Epitope Species: human

Product Reactivity/Detection: TBRG4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TBRG4 Antibody (F-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin