TBP Antibody (A-6): sc-74595

TBP Antibody (A-6) is a mouse monoclonal IgG2b antibody that detects TBP in various species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TBP antibody (A-6) specifically targets the TATA-binding protein (TBP), a crucial component of the transcription machinery in eukaryotic cells. TBP plays a vital role in the initiation of transcription by RNA polymerase II, as TBP binds to the TATA box, a core promoter element typically located 25-30 base pairs upstream of the transcription start site. This binding is essential for the recruitment of other transcription factors and the formation of the pre-initiation complex, which is necessary for accurate transcription of protein-coding genes. TBP is characterized by a highly conserved C-terminal domain of 180 amino acids, which is critical for DNA interaction and function. Understanding TBP′s role in transcription regulation is important for elucidating the mechanisms of gene expression and implications in various biological processes and diseases. TBP monoclonal antibody (A-6) serves as an invaluable tool for researchers studying transcriptional regulation and cellular function.

The preferred TFIID/TATA Binding Protein/TBP antibody is TFIID/TATA Binding Protein/TBP Antibody (58C9): sc-421.