TBL1X Antibody (F-2): sc-365661
- TBL1X Antibody (F-2) is a mouse monoclonal IgG1 TBL1X antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 119-148 within an internal region of TBL1X of human origin
- TBL1X Antibody (F-2) is recommended for detection of TBL1X of human origin by WB, IP, IF and ELISA
- Anti-TBL1X Antibody (F-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-365661 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for TBL1X Antibody (F-2) for WB applications. This reagent is now offered in a bundle with TBL1X Antibody (F-2) (see ordering information below).
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TBL1X Antibody (F-2) is a mouse monoclonal IgG1 antibody that detects TBL1X of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TBL1X (F-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBL1X, also known as transducin β-like 1, plays a critical role in gene expression regulation by participating in ubiquitin/19S proteasome complex recruitment to nuclear receptor-regulated transcription units. This function maintains cellular homeostasis and regulates various biological processes, including development and metabolism. TBL1X functions as part of the N-CoR repressor complex, which includes N-CoR1, N-CoR2, HDAC3, TBL1R, CORO2A, and GPS2, while also operating within the E3 ubiquitin ligase complex. TBL1X interacts with histones H2B, H3a, and H4, highlighting TBL1X′s importance in chromatin remodeling and transcriptional regulation. Located on chromosome Xp22.3, TBL1X is crucial for nuclear receptor-mediated transcription activation, and TBL1X defects can lead to X-linked disorders such as ocular albinism with late-onset sensorineural deafness. The relationship between TBL1X and TBL1Y homolog on the Y chromosome emphasizes these proteins′ significance in sex-linked genetic functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBL1X Antibody (F-2) References:
- X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats. | Bassi, MT., et al. 1999. Am J Hum Genet. 64: 1604-16. PMID: 10330347
- A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. | Guenther, MG., et al. 2000. Genes Dev. 14: 1048-57. PMID: 10809664
- Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. | Yoon, HG., et al. 2003. EMBO J. 22: 1336-46. PMID: 12628926
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. | Skaletsky, H., et al. 2003. Nature. 423: 825-37. PMID: 12815422
- A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. | Perissi, V., et al. 2004. Cell. 116: 511-26. PMID: 14980219
- Reading and function of a histone code involved in targeting corepressor complexes for repression. | Yoon, HG., et al. 2005. Mol Cell Biol. 25: 324-35. PMID: 15601853
- Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness. | Yan, HT., et al. 2005. J Hum Genet. 50: 175-181. PMID: 15834507
- Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes. | Disteche, CM., et al. 1998. Mamm Genome. 9: 1062-4. PMID: 9880679
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBL1X Antibody (F-2) | sc-365661 | 200 µg/ml | $322.00 | |||
TBL1X Antibody (F-2): m-IgG Fc BP-HRP Bundle | sc-525892 | 200 µg Ab; 10 µg BP | $361.00 | |||
TBL1X Antibody (F-2) X | sc-365661 X | 200 µg/0.1 ml | $322.00 | |||
TBL1X Antibody (F-2) AC | sc-365661 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TBL1X Antibody (F-2) HRP | sc-365661 HRP | 200 µg/ml | $322.00 | |||
TBL1X Antibody (F-2) FITC | sc-365661 FITC | 200 µg/ml | $336.00 | |||
TBL1X Antibody (F-2) PE | sc-365661 PE | 200 µg/ml | $349.00 | |||
TBL1X Antibody (F-2) Alexa Fluor® 488 | sc-365661 AF488 | 200 µg/ml | $364.00 | |||
TBL1X Antibody (F-2) Alexa Fluor® 546 | sc-365661 AF546 | 200 µg/ml | $364.00 | |||
TBL1X Antibody (F-2) Alexa Fluor® 594 | sc-365661 AF594 | 200 µg/ml | $364.00 | |||
TBL1X Antibody (F-2) Alexa Fluor® 647 | sc-365661 AF647 | 200 µg/ml | $364.00 | |||
TBL1X Antibody (F-2) Alexa Fluor® 680 | sc-365661 AF680 | 200 µg/ml | $364.00 | |||
TBL1X Antibody (F-2) Alexa Fluor® 790 | sc-365661 AF790 | 200 µg/ml | $364.00 | |||
TBL1X (F-2) Neutralizing Peptide | sc-365661 P | 100 µg/0.5 ml | $69.00 |