TBCEL Antibody (AT1B10): sc-517427

TBCEL Antibody (AT1B10) is a mouse monoclonal IgG2b kappa light chain antibody that detects TBCEL protein of human origin by western blotting (WB), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-TBCEL antibody (AT1B10) is available as the non-conjugated format. TBCEL, or tubulin-folding cofactor E-like protein, is a crucial 424 amino acid cytoplasmic protein that plays a significant role in regulating tubulin stability, which is essential for maintaining the integrity of the cytoskeleton and facilitating cellular processes such as division and intracellular transport. TBCEL is predominantly expressed in the testis but is also found in various other tissues at lower levels, indicating potential involvement in diverse biological functions. Structurally, TBCEL features seven leucine-rich repeats, one LRRCT domain, and one ubiquitin-like domain, which are important for interactions and regulatory functions. The gene encoding TBCEL spans 66,704 bases and is located on human chromosome 11q23.3, a region associated with several genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome, highlighting TBCEL′s importance in human health and disease.

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TBCEL Antibody (AT1B10) References:

1. Hereditary angioedema. Long-term follow-up of 88 patients. Experience of the Argentine Allergy and Immunology Institute.  |  Fabiani, JE., et al. 2000. Allergol Immunopathol (Madr). 28: 267-71. PMID: 11270087
2. Smith-Lemli-Opitz syndrome and the DHCR7 gene.  |  Jira, PE., et al. 2003. Ann Hum Genet. 67: 269-80. PMID: 12914579
3. Identification of a novel tubulin-destabilizing protein related to the chaperone cofactor E.  |  Bartolini, F., et al. 2005. J Cell Sci. 118: 1197-207. PMID: 15728251
4. The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease.  |  Schuchman, EH. 2007. J Inherit Metab Dis. 30: 654-63. PMID: 17632693
5. Jervell and Lange-Nielsen syndrome in Norwegian children: aspects around cochlear implantation, hearing, and balance.  |  Siem, G., et al. 2008. Ear Hear. 29: 261-9. PMID: 18595190
6. Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome).  |  Coldren, CD., et al. 2009. Neurogenetics. 10: 89-95. PMID: 18855024
7. An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome.  |  Bhuiyan, ZA., et al. 2008. Prog Biophys Mol Biol. 98: 319-27. PMID: 19027783

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBCEL Antibody (AT1B10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TBCEL Antibody (AT1B10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBCEL Antibody (AT1B10) Specifications

Alternate Product Name: TBCEL

Product Clone Name: AT1B10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-424

Epitope Target: TBCEL

Epitope Species: human

Product Reactivity/Detection: TBCEL

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TBCEL Antibody (AT1B10): N/A