TBCB Antibody (B-12): sc-377139

TBCB Antibody (B-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBCB protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TBCB antibody (B-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBCB protein, also known as tubulin folding cofactor B, plays a crucial role in the assembly and regulation of microtubules, which are essential components of the cytoskeleton. Microtubules are dynamic structures that provide structural support and facilitate intracellular transport, cell division, and motility. TBCB is involved in the proper folding of tubulin heterodimers, which are the building blocks of microtubules, and acts as a negative regulator of axonal growth, highlighting its importance in neuronal development and function. TBCB consists of 244 amino acids and contains a CAP-Gly domain, indicating potential interactions with other cytoskeletal proteins. TBCB is widely expressed in various tissues, underscoring its fundamental role in cellular architecture and dynamics.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TBCB Antibody (B-12) References:

1. Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization.  |  Grynberg, M., et al. 2003. BMC Bioinformatics. 4: 46. PMID: 14536023
2. p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.  |  Vadlamudi, RK., et al. 2005. Mol Cell Biol. 25: 3726-36. PMID: 15831477
3. Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway.  |  Wang, W., et al. 2005. Curr Biol. 15: 2050-5. PMID: 16303566
4. Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation.  |  Kortazar, D., et al. 2007. Exp Cell Res. 313: 425-36. PMID: 17184771
5. Tubulin cofactor B plays a role in the neuronal growth cone.  |  Lopez-Fanarraga, M., et al. 2007. J Neurochem. 100: 1680-7. PMID: 17217416
6. Tubulin cofactor B regulates microtubule densities during microglia transition to the reactive states.  |  Fanarraga, ML., et al. 2009. Exp Cell Res. 315: 535-41. PMID: 19038251
7. Pathway leading to correctly folded beta-tubulin.  |  Tian, G., et al. 1996. Cell. 86: 287-96. PMID: 8706133
8. Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors.  |  Tian, G., et al. 1997. J Cell Biol. 138: 821-32. PMID: 9265649

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBCB Antibody (B-12) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-TBCB Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBCB Antibody (B-12) Specifications

Alternate Product Name: TBCB

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 19-29

Epitope Target: TBCB

Epitope Species: human

Product Reactivity/Detection: TBCB

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for TBCB Antibody (B-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin