TBC1D7 Antibody (C-9): sc-514595
- TBC1D7 Antibody (C-9) is a mouse monoclonal IgG2b κ TBC1D7 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-16 at the N-terminus of TBC1D7 of human origin
- TBC1D7 Antibody (C-9) is recommended for detection of TBC1D7 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TBC1D7 Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TBC1D7 Antibody (C-9). This work is in progress.
TBC1D7 Antibody (C-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects TBC1D7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TBC1D7 (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBC1D7, also known as PIG51 or cell migration-inducing protein 23, is a 293 amino acid protein that plays a crucial role in cellular processes by localizing to the cytoplasmic vesicles of the endomembrane system, where TBC1D7 interacts with the hamartin-tuberin complex. This localization positions TBC1D7 to regulate the GTPase activity of Rab proteins, which are essential for vesicle trafficking and cellular signaling. TBC1D7 negatively regulates hamartin through the activation of the mechanistic target of rapamycin (mTOR) pathway, highlighting TBC1D7′s importance in cellular growth and metabolism. TBC1D7 exists in two alternatively spliced isoforms and is predominantly expressed in the heart, with lower levels found in the placenta, kidney, and liver. TBC1D7 contains a Rab-GAP TBC domain and is encoded by a gene located on human chromosome 6, which is notable for its association with various diseases, including early onset intestinal cancer and other genetic disorders. Research on TBC1D7 and its interactions is vital for understanding TBC1D7′s role in cellular dynamics and potential implications in cancer susceptibility and other health conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBC1D7 Antibody (C-9) References:
- Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. | Cesari, R., et al. 2003. Proc Natl Acad Sci U S A. 100: 5956-61. PMID: 12719539
- Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex. | Nakashima, A., et al. 2007. Biochem Biophys Res Commun. 361: 218-23. PMID: 17658474
- Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22. | Bläker, H., et al. 2008. Genes Chromosomes Cancer. 47: 159-64. PMID: 18008368
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. | Ishibashi, K., et al. 2009. Genes Cells. 14: 41-52. PMID: 19077034
- Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. | Fan, J., et al. 2010. Am J Med Genet B Neuropsychiatr Genet. 153B: 29-37. PMID: 19308960
- Associations among behavior-related susceptibility factors in porphyria cutanea tarda. | Jalil, S., et al. 2010. Clin Gastroenterol Hepatol. 8: 297-302, 302.e1. PMID: 19948245
- A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene. | Brunner, HG., et al. 1994. Hum Mol Genet. 3: 1561-4. PMID: 7833911
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBC1D7 Antibody (C-9) | sc-514595 | 200 µg/ml | $322.00 | |||
TBC1D7 Antibody (C-9) AC | sc-514595 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TBC1D7 Antibody (C-9) HRP | sc-514595 HRP | 200 µg/ml | $322.00 | |||
TBC1D7 Antibody (C-9) FITC | sc-514595 FITC | 200 µg/ml | $336.00 | |||
TBC1D7 Antibody (C-9) PE | sc-514595 PE | 200 µg/ml | $349.00 | |||
TBC1D7 Antibody (C-9) Alexa Fluor® 488 | sc-514595 AF488 | 200 µg/ml | $364.00 | |||
TBC1D7 Antibody (C-9) Alexa Fluor® 546 | sc-514595 AF546 | 200 µg/ml | $364.00 | |||
TBC1D7 Antibody (C-9) Alexa Fluor® 594 | sc-514595 AF594 | 200 µg/ml | $364.00 | |||
TBC1D7 Antibody (C-9) Alexa Fluor® 647 | sc-514595 AF647 | 200 µg/ml | $364.00 | |||
TBC1D7 Antibody (C-9) Alexa Fluor® 680 | sc-514595 AF680 | 200 µg/ml | $364.00 | |||
TBC1D7 Antibody (C-9) Alexa Fluor® 790 | sc-514595 AF790 | 200 µg/ml | $364.00 | |||
TBC1D7 (C-9) Neutralizing Peptide | sc-514595 P | 100 µg/0.5 ml | $69.00 |