TBC1D5 Antibody (E-9): sc-376296

TBC1D5 Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBC1D5 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-TBC1D5 antibody (E-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBC1D5, also known as KIAA0210, is a 795 amino acid protein that functions as a GTPase-activating protein for Rab family members, playing a crucial role in regulating intracellular vesicle trafficking. By accelerating the intrinsic rate of GTP hydrolysis, TBC1D5 downregulates the active form of Rab proteins, which is essential for maintaining cellular homeostasis and proper signaling pathways. The gene encoding TBC1D5 is located on human chromosome 3, a region associated with various genetic diseases and key tumor suppressor genes, including those involved in apoptosis and cell migration. Understanding TBC1D5 function is vital, as dysregulation of Rab proteins can lead to numerous pathologies, including cancer and neurodegenerative diseases.

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TBC1D5 Antibody (E-9) References:

1. [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification].  |  Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
2. Plasticity of human chromosome 3 during primate evolution.  |  Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.  |  Brill, LM., et al. 2004. Anal Chem. 76: 2763-72. PMID: 15144186
4. Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution.  |  Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.  |  Lim, J., et al. 2006. Cell. 125: 801-14. PMID: 16713569
6. High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene.  |  Nair, PN., et al. 2007. Cancer Genet Cytogenet. 174: 100-10. PMID: 17452250
7. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.  |  Ishibashi, K., et al. 2009. Genes Cells. 14: 41-52. PMID: 19077034
8. Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling.  |  Carosi, JM., et al. 2024. Autophagy. 20: 863-882. PMID: 37938196
9. TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy.  |  Huang, Y., et al. 2024. J Transl Med. 22: 212. PMID: 38419050
10. SARS-CoV-2 virulence factor ORF3a blocks lysosome function by modulating TBC1D5-dependent Rab7 GTPase cycle.  |  Walia, K., et al. 2024. Nat Commun. 15: 2053. PMID: 38448435
11. Enhancing Rab7 Activity by Inhibiting TBC1D5 Expression Improves Mitophagy in Alzheimer's Disease Models.  |  Liang, X., et al. 2024. J Alzheimers Dis. 100: 279-296. PMID: 38848175
12. Mutilating neuropathic ulcerations in a chromosome 3q13-q22 linked Charcot-Marie-Tooth disease type 2B family.  |  De Jonghe, P., et al. 1997. J Neurol Neurosurg Psychiatry. 62: 570-3. PMID: 9219740

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TBC1D5 Antibody (E-9) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-TBC1D5 Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TBC1D5 Antibody (E-9) Specifications

Alternate Product Name: TBC1D5

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 771-794

Epitope Target: TBC1D5

Epitope Species: human

Product Reactivity/Detection: TBC1D5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for TBC1D5 Antibody (E-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin