TBC1D24 Antibody (G-6): sc-390237
- TBC1D24 Antibody (G-6) is a mouse monoclonal IgG1 κ TBC1D24 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 437-559 at the C-terminus of TBC1D24 of human origin
- TBC1D24 Antibody (G-6) is recommended for detection of TBC1D24 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- Anti-TBC1D24 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TBC1D24 Antibody (G-6) for WB applications. These reagents are now offered in bundles with TBC1D24 Antibody (G-6) (see ordering information below).
TBC1D24 Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects TBC1D24 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TBC1D24 (G-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TBC1D24, which consists of 559 amino acids, is primarily located in the cytoplasm and plays a crucial role as a GTPase-activating protein for Rab family proteins, specifically modulating their activity. This function is vital for regulating intracellular trafficking and maintaining cellular homeostasis, particularly in neuronal cells where TBC1D24 is highly expressed. TBC1D24 is also found in other tissues such as the testis, skeletal muscle, heart, kidney, lung, and liver. Notably, defects in TBC1D24 are linked to familial infantile myoclonic epilepsy (FIME), a severe form of epilepsy that manifests in early infancy with symptoms including myoclonic seizures and tonic-clonic seizures. TBC1D24 spans 28,353 bases and is located on human chromosome 16p13.3, highlighting its significance in both neurological function and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TBC1D24 Antibody (G-6) References:
- Mapping of a locus for a familial autosomal recessive idiopathic myoclonic epilepsy of infancy to chromosome 16p13. | Zara, F., et al. 2000. Am J Hum Genet. 66: 1552-7. PMID: 10741954
- Functions of Rac GTPases during neuronal development. | de Curtis, I. 2008. Dev Neurosci. 30: 47-58. PMID: 18075254
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. | Ishibashi, K., et al. 2009. Genes Cells. 14: 41-52. PMID: 19077034
- TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy. | Falace, A., et al. 2010. Am J Hum Genet. 87: 365-70. PMID: 20727515
- A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24. | Corbett, MA., et al. 2010. Am J Hum Genet. 87: 371-5. PMID: 20797691
- TBC proteins: GAPs for mammalian small GTPase Rab? | Fukuda, M. 2011. Biosci Rep. 31: 159-68. PMID: 21250943
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TBC1D24 Antibody (G-6) | sc-390237 | 200 µg/ml | $316.00 | |||
TBC1D24 Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-523459 | 200 µg Ab, 40 µg BP | $354.00 | |||
TBC1D24 Antibody (G-6): m-IgG1 BP-HRP Bundle | sc-533585 | 200 µg Ab; 20 µg BP | $354.00 | |||
TBC1D24 Antibody (G-6) AC | sc-390237 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TBC1D24 Antibody (G-6) HRP | sc-390237 HRP | 200 µg/ml | $316.00 | |||
TBC1D24 Antibody (G-6) FITC | sc-390237 FITC | 200 µg/ml | $330.00 | |||
TBC1D24 Antibody (G-6) PE | sc-390237 PE | 200 µg/ml | $343.00 | |||
TBC1D24 Antibody (G-6) Alexa Fluor® 488 | sc-390237 AF488 | 200 µg/ml | $357.00 | |||
TBC1D24 Antibody (G-6) Alexa Fluor® 546 | sc-390237 AF546 | 200 µg/ml | $357.00 | |||
TBC1D24 Antibody (G-6) Alexa Fluor® 594 | sc-390237 AF594 | 200 µg/ml | $357.00 | |||
TBC1D24 Antibody (G-6) Alexa Fluor® 647 | sc-390237 AF647 | 200 µg/ml | $357.00 | |||
TBC1D24 Antibody (G-6) Alexa Fluor® 680 | sc-390237 AF680 | 200 µg/ml | $357.00 | |||
TBC1D24 Antibody (G-6) Alexa Fluor® 790 | sc-390237 AF790 | 200 µg/ml | $357.00 | |||
TBC1D24 (G-6) Neutralizing Peptide | sc-390237 P | 100 µg/0.5 ml | $68.00 |