TATDN1 Antibody (B-2): sc-376053
- TATDN1 Antibody (B-2) is a mouse monoclonal IgG2b κ TATDN1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 217-253 within an internal region of TATDN1 of human origin
- TATDN1 Antibody (B-2) is recommended for detection of TATDN1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TATDN1 Antibody (B-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TATDN1 Antibody (B-2) for WB and IHC(P) applications. These reagents are now offered in bundles with TATDN1 Antibody (B-2) (see ordering information below).
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TATDN1 Antibody (B-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects TATDN1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-TATDN1 antibody (B-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TATDN1, also known as CDA11, is a 297 amino acid nuclear protein that belongs to the TatD DNase family and plays a crucial role in DNA repair and maintenance of genomic stability. TATDN1 (B-2) antibody targets a protein involved in degrading damaged DNA, preventing mutation accumulation that could lead to various diseases, including cancer. TATDN1 exists in two isoforms due to alternative splicing events and is encoded by a gene located on human chromosome 8, which is associated with numerous genetic disorders and malignancies. TATDN1′s presence in the nucleus highlights its significance in cellular processes, and its interaction with other proteins involved in DNA repair pathways further underscores its essential role in maintaining cellular integrity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TATDN1 Antibody (B-2) References:
- Chromosomes 8 and 10 workshop. | Wildenauer, DB. and Schwab, SG. 1999. Am J Med Genet. 88: 239-43. PMID: 10374738
- Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. | Still, IH., et al. 1999. Oncogene. 18: 4032-8. PMID: 10435627
- Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced. | Kashino, G., et al. 2001. Biochem Biophys Res Commun. 289: 111-5. PMID: 11708785
- Cytogenetic mapping of a novel locus for type II Waardenburg syndrome. | Selicorni, A., et al. 2002. Hum Genet. 110: 64-7. PMID: 11810298
- Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution. | Boniotto, M., et al. 2004. Genet Test. 8: 325-7. PMID: 15727258
- Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. | McQueen, MB., et al. 2005. Am J Hum Genet. 77: 582-95. PMID: 16175504
- DNA sequence and analysis of human chromosome 8. | Nusbaum, C., et al. 2006. Nature. 439: 331-5. PMID: 16421571
- Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. | Agrelo, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 8822-7. PMID: 16723399
- Non-Hodgkin's lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis. | Mossafa, H., et al. 2006. Leuk Lymphoma. 47: 1885-93. PMID: 17065002
- Characterization of the region of the short arm of chromosome 8 amplified in breast carcinoma. | Dib, A., et al. 1995. Oncogene. 10: 995-1001. PMID: 7898940
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TATDN1 Antibody (B-2) | sc-376053 | 200 µg/ml | $316.00 | |||
TATDN1 Antibody (B-2): m-IgGκ BP-HRP Bundle | sc-522834 | 200 µg Ab, 40 µg BP | $354.00 | |||
TATDN1 Antibody (B-2): m-IgG2b BP-HRP Bundle | sc-549075 | 200 µg Ab; 10 µg BP | $354.00 | |||
TATDN1 Antibody (B-2) AC | sc-376053 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TATDN1 Antibody (B-2) HRP | sc-376053 HRP | 200 µg/ml | $316.00 | |||
TATDN1 Antibody (B-2) FITC | sc-376053 FITC | 200 µg/ml | $330.00 | |||
TATDN1 Antibody (B-2) PE | sc-376053 PE | 200 µg/ml | $343.00 | |||
TATDN1 Antibody (B-2) Alexa Fluor® 488 | sc-376053 AF488 | 200 µg/ml | $357.00 | |||
TATDN1 Antibody (B-2) Alexa Fluor® 546 | sc-376053 AF546 | 200 µg/ml | $357.00 | |||
TATDN1 Antibody (B-2) Alexa Fluor® 594 | sc-376053 AF594 | 200 µg/ml | $357.00 | |||
TATDN1 Antibody (B-2) Alexa Fluor® 647 | sc-376053 AF647 | 200 µg/ml | $357.00 | |||
TATDN1 Antibody (B-2) Alexa Fluor® 680 | sc-376053 AF680 | 200 µg/ml | $357.00 | |||
TATDN1 Antibody (B-2) Alexa Fluor® 790 | sc-376053 AF790 | 200 µg/ml | $357.00 | |||
TATDN1 (B-2) Neutralizing Peptide | sc-376053 P | 100 µg/0.5 ml | $68.00 |