TASK-2 Antibody (F-7): sc-271836

TASK-2 Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects TASK-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TASK-2 (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TASK-2 protein is a member of the tandem pore potassium channel family, which plays a crucial role in maintaining the resting membrane potential and regulating neuronal excitability. TASK-2 is predominantly expressed in the kidney, where TASK-2 is localized in the cortical distal tubules and collecting ducts, indicating significant involvement in renal potassium transport and homeostasis. This localization helps regulate electrolyte balance and blood pressure, making TASK-2 an important target for understanding renal function and potential therapeutic interventions in conditions such as hypertension and electrolyte disorders. TASK-2 channels are known for sensitivity to changes in extracellular pH, which further underscores physiological relevance in various cellular processes.

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TASK-2 Antibody (F-7) References:

1. Activation of the TASK-2 channel after cell swelling is dependent on tyrosine phosphorylation.  |  Kirkegaard, SS., et al. 2010. Am J Physiol Cell Physiol. 299: C844-53. PMID: 20631251
2. B lymphocytes taken to task: a role for a background conductance K2P K+ channel in B cells. Focus on 'Expression of TASK-2 and its upregulation by B cell receptor stimulation in WEHI-231 mouse immature B cells'.  |  Flores, CA., et al. 2011. Am J Physiol Cell Physiol. 300: C976-8. PMID: 21389277
3. TASK-2: a K2P K(+) channel with complex regulation and diverse physiological functions.  |  Cid, LP., et al. 2013. Front Physiol. 4: 198. PMID: 23908634
4. Zebrafish and mouse TASK-2 K(+) channels are inhibited by increased CO2 and intracellular acidification.  |  Peña-Münzenmayer, G., et al. 2014. Pflugers Arch. 466: 1317-27. PMID: 24081451
5. Lower expression of the TWIK-related acid-sensitive K+ channel 2 (TASK-2) gene is a hallmark of aldosterone-producing adenoma causing human primary aldosteronism.  |  Lenzini, L., et al. 2014. J Clin Endocrinol Metab. 99: E674-82. PMID: 24285684
6. HIF-1α-mediated upregulation of TASK-2 K⁺ channels augments Ca²⁺ signaling in mouse B cells under hypoxia.  |  Shin, DH., et al. 2014. J Immunol. 193: 4924-33. PMID: 25305321
7. TASK-2 K₂p K⁺ channel: thoughts about gating and its fitness to physiological function.  |  López-Cayuqueo, KI., et al. 2015. Pflugers Arch. 467: 1043-53. PMID: 25315981
8. Phosphatidylinositol (4,5)-bisphosphate dynamically regulates the K2P background K+ channel TASK-2.  |  Niemeyer, MI., et al. 2017. Sci Rep. 7: 45407. PMID: 28358046
9. K2P TASK-2 and KCNQ1-KCNE3 K+ channels are major players contributing to intestinal anion and fluid secretion.  |  Julio-Kalajzić, F., et al. 2018. J Physiol. 596: 393-407. PMID: 29143340
10. Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels.  |  Bustos, D., et al. 2020. Int J Mol Sci. 21: PMID: 31947679
11. Central respiratory chemoreception.  |  Guyenet, PG. and Bayliss, DA. 2022. Handb Clin Neurol. 188: 37-72. PMID: 35965033
12. TWIK-related acid-sensitive K+ channel 2 promotes renal fibrosis by inducing cell-cycle arrest.  |  Zhang, J., et al. 2022. iScience. 25: 105620. PMID: 36465115

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TASK-2 Antibody (F-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TASK-2 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TASK-2 Antibody (F-7) Specifications

Alternate Product Name: TASK-2

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 330-499

Epitope Target: TASK-2

Epitope Species: human

Product Reactivity/Detection: TASK-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TASK-2 Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin