TARSH Antibody (H-8): sc-398847
- TARSH Antibody (H-8) is a mouse monoclonal IgG1 κ TARSH antibody provided at 200 µg/ml
- raised against amino acids 786-900 mapping within an internal region of TARSH of human origin
- TARSH Antibody (H-8) is recommended for detection of TARSH of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TARSH Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TARSH Antibody (H-8) for WB applications. These reagents are now offered in bundles with TARSH Antibody (H-8) (see ordering information below).
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TARSH Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects TARSH protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TARSH (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TARSH protein, also known as ABI family member 3 (NESH) binding protein, plays a crucial role in cellular senescence and tumor suppression, making TARSH significant in cancer research. TARSH (H-8) monoclonal antibody targets a protein involved in regulating cellular signaling pathways and interacts with Abi-3, a protein that inhibits ectopic metastasis of tumor cells, highlighting TARSH importance in cancer progression and metastasis. TARSH consists of 1,075 amino acids and is expressed in various tissues, including brain, lung, heart, liver, placenta, pancreas, and kidney, with four isoforms resulting from alternative splicing. TARSH contains a SH3 binding motif and a nuclear targeting sequence, which are essential for function in cellular processes. TARSH gene is located on human chromosome 3, a region encompassing over 1,100 genes, including several associated with cancer. Loss of TARSH expression has been implicated in cancer pathogenesis, particularly in thyroid and lung, underscoring anti-TARSH antibody (H-8) relevance in both basic and translational research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TARSH Antibody (H-8) References:
- Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. | Matsuda, S., et al. 2001. J Hum Genet. 46: 483-6. PMID: 11501947
- [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification]. | Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
- Plasticity of human chromosome 3 during primate evolution. | Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
- Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer. | Uekawa, N., et al. 2005. Biochem Biophys Res Commun. 329: 1031-8. PMID: 15752759
- Cancer-associated loss of TARSH gene expression in human primary lung cancer. | Terauchi, K., et al. 2006. J Cancer Res Clin Oncol. 132: 28-34. PMID: 16205947
- Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression. | Wakoh, T., et al. 2009. Biochem Biophys Res Commun. 380: 807-12. PMID: 19338757
- Mutilating neuropathic ulcerations in a chromosome 3q13-q22 linked Charcot-Marie-Tooth disease type 2B family. | De Jonghe, P., et al. 1997. J Neurol Neurosurg Psychiatry. 62: 570-3. PMID: 9219740
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TARSH Antibody (H-8) | sc-398847 | 200 µg/ml | $322.00 | |||
TARSH Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-527824 | 200 µg Ab; 10 µg BP | $361.00 | |||
TARSH Antibody (H-8): m-IgG1 BP-HRP Bundle | sc-533197 | 200 µg Ab; 20 µg BP | $361.00 | |||
TARSH Antibody (H-8) AC | sc-398847 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TARSH Antibody (H-8) HRP | sc-398847 HRP | 200 µg/ml | $322.00 | |||
TARSH Antibody (H-8) FITC | sc-398847 FITC | 200 µg/ml | $336.00 | |||
TARSH Antibody (H-8) PE | sc-398847 PE | 200 µg/ml | $349.00 | |||
TARSH Antibody (H-8) Alexa Fluor® 488 | sc-398847 AF488 | 200 µg/ml | $364.00 | |||
TARSH Antibody (H-8) Alexa Fluor® 546 | sc-398847 AF546 | 200 µg/ml | $364.00 | |||
TARSH Antibody (H-8) Alexa Fluor® 594 | sc-398847 AF594 | 200 µg/ml | $364.00 | |||
TARSH Antibody (H-8) Alexa Fluor® 647 | sc-398847 AF647 | 200 µg/ml | $364.00 | |||
TARSH Antibody (H-8) Alexa Fluor® 680 | sc-398847 AF680 | 200 µg/ml | $364.00 | |||
TARSH Antibody (H-8) Alexa Fluor® 790 | sc-398847 AF790 | 200 µg/ml | $364.00 |