TARBP1 Antibody (G-3): sc-514838

TARBP1 Antibody (G-3) is a mouse monoclonal IgG2a antibody that detects TARBP1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TARBP1 antibody (G-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TARBP1, also known as TAR RNA-binding protein 1, plays a crucial role in regulating HIV-1 gene expression by binding to the loop region of TAR RNA during HIV-1 infection, a region also recognized by RNA polymerase II. This interaction is significant because TARBP1 facilitates the disengagement of RNA polymerase II from TAR RNA, thereby influencing the transcriptional activity of the virus. Additionally, TARBP1 is part of a complex network involving other proteins such as TRBP2, which further modulates the viral life cycle and host responses. Understanding TARBP1 function is essential for elucidating the mechanisms of HIV-1 pathogenesis and may provide insights into potential therapeutic targets for antiviral strategies.

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TARBP1 Antibody (G-3) References:

1. The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR.  |  Dorin, D., et al. 2003. J Biol Chem. 278: 4440-8. PMID: 12475984
2. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.  |  Chendrimada, TP., et al. 2005. Nature. 436: 740-4. PMID: 15973356
3. tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185.  |  Wu, F., et al. 1991. Genes Dev. 5: 2128-40. PMID: 1936997
4. Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR.  |  Gatignol, A., et al. 1991. Science. 251: 1597-600. PMID: 2011739
5. Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat.  |  Wu-Baer, F., et al. 1995. Proc Natl Acad Sci U S A. 92: 7153-7. PMID: 7638159
6. Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1).  |  Kozak, CA., et al. 1995. Genomics. 25: 66-72. PMID: 7774957
7. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.  |  Wu-Baer, F., et al. 1996. J Biol Chem. 271: 4201-8. PMID: 8626763
8. The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA.  |  Wu-Baer, F., et al. 1995. EMBO J. 14: 5995-6009. PMID: 8846792

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TARBP1 Antibody (G-3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TARBP1 Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TARBP1 Antibody (G-3) Specifications

Alternate Product Name: TARBP1

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids: 1344-1563

Epitope Target: TARBP1

Epitope Species: human

Product Reactivity/Detection: TARBP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TARBP1 Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin