Tara Antibody (G-9): sc-377474

Tara Antibody (G-9) is a mouse monoclonal IgG3 kappa light chain antibody that detects Tara protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Tara (G-9) antibody is available as the non-conjugated form. Tara protein, also known as TRIOBP (trio and F-actin-binding protein) or DFNB28, is a crucial component in neural tissue development and actin cytoskeleton organization, with highest expression levels in heart and placenta. Tara primarily localizes in nucleus and cytoplasm, playing a significant role in stabilizing F-actin structures and influencing cell growth and motility. Tara features a pleckstrin homology domain at N-terminus and a coiled-coil region at C-terminus, essential for interactions with Trio, TRF1, and F-actin. These interactions maintain cytoskeleton integrity and facilitate cellular processes. Mutations in Tara can lead to autosomal recessive nonsyndromic sensorineural deafness type 28 (DFNB28), highlighting Tara′s importance in auditory function. Five isoforms of Tara exist due to alternative splicing, with isoform 3, known as the long isoform, being exclusively expressed in fetal retina, cochlea, and brain, further underscoring Tara′s diverse roles in development and cellular dynamics.

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Tara Antibody (G-9) References:

1. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization.  |  Seipel, K., et al. 2001. J Cell Sci. 114: 389-99. PMID: 11148140
2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.  |  Hirosawa, M., et al. 2001. DNA Res. 8: 1-9. PMID: 11258795
3. [Isolation of Tara protein and its gene cloning].  |  Lan, JP., et al. 2004. Zhejiang Da Xue Xue Bao Yi Xue Ban. 33: 486-90. PMID: 15586403
4. Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness.  |  Riazuddin, S., et al. 2006. Am J Hum Genet. 78: 137-43. PMID: 16385457
5. Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss.  |  Shahin, H., et al. 2006. Am J Hum Genet. 78: 144-52. PMID: 16385458
6. Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung.  |  Sugaya, M., et al. 2007. Int J Cancer. 120: 1055-62. PMID: 17131342
7. Expression, purification, and characterization of Tara, a novel telomere repeat-binding factor 1 (TRF1)-binding protein.  |  Li, X., et al. 2007. Protein Expr Purif. 55: 84-92. PMID: 17629495

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Tara Antibody (G-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Tara Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Tara Antibody (G-9) Specifications

Alternate Product Name: Tara

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 2214-2283

Epitope Target: Tara

Epitope Species: human

Product Reactivity/Detection: Tara

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Tara Antibody (G-9): N/A