TaR Antibody (D-7): sc-398096

TaR Antibody (D-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects TaR protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-TaR antibody (D-7) is available as the non-conjugated form. TaR protein, part of the trace-amine-associated receptor family, plays a crucial role in the detection of social cues and is implicated in various neuropsychiatric conditions. These receptors are activated by trace amines, which are endogenous molecules structurally related to classical biogenic amines and are found in low levels in mammalian tissues. The unique structure of TaRs, which includes seven transmembrane regions similar to those found in the rhodopsin β-adrenergic receptor superfamily, allows for specific ligand-binding interactions that are essential for their function. This structural similarity provides insights into the mechanisms of receptor activation and the potential for therapeutic targeting. TaRs are particularly important in the context of drug abuse and neuropsychiatric disorders, as they are potential targets for substances like amphetamine and MDMA, as well as conditions such as schizophrenia, depression, and attention deficit disorder. TaR (D-7) antibody′s ability to effectively detect TaR protein across various applications makes this reagent a valuable tool for researchers studying these critical pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TaR Antibody (D-7) References:

1. Elusive amines and cluster headache: mutational analysis of trace amine receptor cluster on chromosome 6q23.  |  Aridon, P., et al. 2004. Neurol Sci. 25 Suppl 3: S279-80. PMID: 15549560
2. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.  |  Lindemann, L., et al. 2005. Genomics. 85: 372-85. PMID: 15718104
3. Primate trace amine receptor 1 modulation by the dopamine transporter.  |  Miller, GM., et al. 2005. J Pharmacol Exp Ther. 313: 983-94. PMID: 15764732
4. A second class of chemosensory receptors in the olfactory epithelium.  |  Liberles, SD. and Buck, LB. 2006. Nature. 442: 645-50. PMID: 16878137
5. Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1.  |  Wainscott, DB., et al. 2007. J Pharmacol Exp Ther. 320: 475-85. PMID: 17038507

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TaR Antibody (D-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TaR Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TaR Antibody (D-7) Specifications

Alternate Product Name: TaR

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 181-247

Epitope Target: TaR-1

Epitope Species: mouse

Product Reactivity/Detection: TaR-1

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TaR Antibody (D-7): N/A