TAPP2 Antibody (D-2): sc-166593

TAPP2 Antibody (D-2) is a mouse monoclonal IgG2b antibody that detects TAPP2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TAPP2, or tandem PH domain-containing protein 2, is a crucial cytoplasmic adaptor protein that plays a significant role in cellular signaling pathways, particularly in the immune response. TAPP2 is predominantly expressed in heart and kidney tissues, where TAPP2 is involved in the recruitment of signaling molecules to the plasma membrane upon growth factor stimulation. This recruitment is facilitated by the specific interaction of TAPP2′s C-terminal pleckstrin homology domain with phosphatidylinositol 3,4-bisphosphate, which is essential for the formation of membrane ruffles rich in F-Actin. TAPP2′s importance extends to regulatory effects on immune cell activation; TAPP2 enhances NFAT-dependent transcriptional activation following B cell receptor engagement and contributes to the sustained calcium response, thereby influencing the activation of both B and T cells. Anti-TAPP2 antibody (D-2) is an invaluable tool for researchers studying the intricate mechanisms of immune signaling and cellular dynamics.

The preferred TAPP2 antibody is TAPP2 Antibody (A-7): sc-166351.