TAP Antibody (31): sc-136095
- TAP Antibody (31) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 488-596 of TAP of human origin
- recommended for detection of TAP of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TAP Antibody (31). This work is in progress.
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SEE ALSO...
TAP Antibody (31) is a mouse monoclonal IgG1 antibody that detects TAP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). TAP, or tip-associating protein, plays a crucial role in the nuclear export of unspliced viral RNAs, particularly those containing the constitutive transport element (CTE) found in type D retroviruses. This function is vital for the viral life cycle, as TAP ensures that viral RNA is efficiently transported from the nucleus to the cytoplasm, where translation into proteins necessary for viral replication occurs. TAP is part of a well-characterized mRNA export pathway and belongs to the multigene family of NXF proteins, which are evolutionarily conserved and characterized by a leucine-rich-repeat domain followed by a nuclear transport factor 2 (NTF2)-like domain. The interaction of TAP with CTE-containing RNAs highlights TAP′s importance in viral pathogenesis and cellular RNA transport mechanisms, making anti-TAP antibody (31) an essential tool for researchers studying these processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TAP Antibody (31) References:
- Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. | Braun, IC., et al. 2002. Mol Cell Biol. 22: 5405-18. PMID: 12101235
- TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD. | Saito, K., et al. 2004. Biochem Biophys Res Commun. 321: 291-7. PMID: 15358174
- The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable. | Johnson, LA., et al. 2009. J Virol. 83: 6335-46. PMID: 19369354
- Varicella-zoster virus IE4 protein interacts with SR proteins and exports mRNAs through the TAP/NXF1 pathway. | Ote, I., et al. 2009. PLoS One. 4: e7882. PMID: 19924249
- Head-to-tail intramolecular interaction of herpes simplex virus type 1 regulatory protein ICP27 is important for its interaction with cellular mRNA export receptor TAP/NXF1. | Hernandez, FP. and Sandri-Goldin, RM. 2010. mBio. 1: PMID: 21060739
- HIV-1 Rev protein specifies the viral RNA export pathway by suppressing TAP/NXF1 recruitment. | Taniguchi, I., et al. 2014. Nucleic Acids Res. 42: 6645-58. PMID: 24753416
- SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export. | Müller-McNicoll, M., et al. 2016. Genes Dev. 30: 553-66. PMID: 26944680
- Evidence for Viral mRNA Export from Ebola Virus Inclusion Bodies by the Nuclear RNA Export Factor NXF1. | Wendt, L., et al. 2022. J Virol. 96: e0090022. PMID: 36040180
- HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development. | Jin, T., et al. 2024. Adv Sci (Weinh). 11: e2307639. PMID: 38626369
- Cellular NS1-BP protein interacts with the mRNA export receptor NXF1 to mediate nuclear export of influenza virus M mRNAs. | Zhang, K., et al. 2024. J Biol Chem. 300: 107871. PMID: 39384042
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAP Antibody (31) | sc-136095 | 50 µg/0.5 ml | $316.00 |