Tankyrase-1 Antibody (BL-2): sc-130422

Tankyrase-1 Antibody (BL-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Tankyrase-1 protein of mouse, rat, and human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Tankyrase-1 antibody (BL-2) is available as a non-conjugated format. Tankyrase-1, also known as TRF1-interacting ankyrin-related ADP-ribose polymerase 1, plays a crucial role in telomere maintenance and cellular signaling by catalyzing the addition of poly(ADP-ribose) chains to target proteins, a process known as ADP-ribosylation. This post-translational modification regulates various cellular processes, including DNA repair, cell cycle progression, and apoptosis. Tankyrase-1 interacts with several key proteins, such as TRF-1 (telomere-repeat-binding factor 1) and insulin-responsive aminopeptidase (IRAP), which are essential for maintaining telomere integrity and cellular homeostasis. Tankyrase-1′s ability to modulate telomere length by promoting telomerase access to the telomeric complex underscores its importance in cellular aging and cancer biology. Additionally, Tankyrase-1′s ankyrin-repeat domain facilitates interaction with diverse protein partners, thereby influencing multiple signaling pathways. The overlapping functions of Tankyrase-1 and its homolog Tankyrase-2 highlight their significance in cellular regulation and potential as therapeutic targets in diseases associated with telomere dysfunction.

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Tankyrase-1 Antibody (BL-2) References:

1. Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes.  |  Smith, S. and de Lange, T. 1999. J Cell Sci. 112 (Pt 21): 3649-56. PMID: 10523501
2. Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).  |  Sbodio, JI., et al. 2002. Biochem J. 361: 451-9. PMID: 11802774
3. Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis.  |  Bae, J., et al. 2003. J Biol Chem. 278: 5195-204. PMID: 12475993
4. The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity.  |  Schreiber, V., et al. 1992. EMBO J. 11: 3263-9. PMID: 1505517
5. Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.  |  Chiang, YJ., et al. 2008. PLoS One. 3: e2639. PMID: 18612384
6. Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.  |  Ha, GH., et al. 2012. Cell Death Differ. 19: 321-32. PMID: 21818122
7. Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.  |  Uchida, K., et al. 1987. Biochem Biophys Res Commun. 148: 617-22. PMID: 3120710
8. MicroRNA-9-1 Attenuates Influenza A Virus Replication via Targeting Tankyrase 1.  |  Bamunuarachchi, G., et al. 2023. J Innate Immun. 15: 647-664. PMID: 37607510
9. Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation.  |  Mubaid, S., et al. 2024. Nucleic Acids Res. 52: 4002-4020. PMID: 38321934
10. A human telomeric protein.  |  Chong, L., et al. 1995. Science. 270: 1663-7. PMID: 7502076
11. Control of telomere length by the human telomeric protein TRF1.  |  van Steensel, B. and de Lange, T. 1997. Nature. 385: 740-3. PMID: 9034193
12. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.  |  Smith, S., et al. 1998. Science. 282: 1484-7. PMID: 9822378

The preferred Tankyrase-1/2 antibody is Tankyrase-1/2 Antibody (E-10): sc-365897.