TAL1 Antibody (B-8): sc-393288
- TAL1 Antibody (B-8) is a mouse monoclonal mouse IgG2a κ κ provided at 200 µg/ml
- raised against amino acids 272-331 mapping at the C-terminus of TAL1 of human origin
- recommended for detection of TAL1 pp42, pp39 and pp22 isoforms of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- TransCruz reagent for ChIP application (sc-393288 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TAL1 Antibody (B-8) for WB applications. These reagents are now offered in bundles with TAL1 Antibody (B-8) (see ordering information below).
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TAL1 Antibody (B-8) is a mouse monoclonal IgG2a light chain antibody that detects TAL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TAL1, also known as SCL, is a crucial serine phosphoprotein and basic helix-loop-helix transcription factor that plays a significant role in regulating embryonic hematopoiesis, which is essential for the development of blood cells. TAL1 dysregulation is implicated in up to 60% of human T cell acute lymphoblastic leukemia cases, marking TAL1 as the most common gain-of-function mutation in this disease. TAL1 operates by forming heterodimers with other transcription factors such as E2A and HEB/HTF4, binding to specific E-box motifs in DNA to initiate transcription. Furthermore, TAL1 interaction with the catalytic subunit of casein kinase IIalpha, a serine/threonine protein kinase, significantly enhances leukemogenesis, underscoring TAL1′s regulatory mechanisms in both normal hematopoiesis and cancer development. Anti-TAL1 antibody (B-8) serves as an invaluable tool for researchers investigating this transcription factor in various biological processes and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TAL1 Antibody (B-8) References:
- microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. | Correia, NC., et al. 2016. Oncotarget. 7: 8268-81. PMID: 26882564
- The Role of TAL1 in Hematopoiesis and Leukemogenesis. | Vagapova, ER., et al. 2018. Acta Naturae. 10: 15-23. PMID: 29713515
- TAL1 mediates imatinib-induced CML cell apoptosis via the PTEN/PI3K/AKT pathway. | Wu, Y., et al. 2019. Biochem Biophys Res Commun. 519: 234-239. PMID: 31493871
- Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis. | Li, Y., et al. 2020. Nucleic Acids Res. 48: 3119-3133. PMID: 32086528
- TAL1 cooperates with PI3K/AKT pathway activation in T-cell acute lymphoblastic leukemia. | Thielemans, N., et al. 2022. Haematologica. 107: 2304-2317. PMID: 35354248
- The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis. | Yamada, Y., et al. 2022. Sci Rep. 12: 7226. PMID: 35508511
- Harnessing the MYB-dependent TAL1 5'super-enhancer for targeted therapy in T-ALL. | Smith, C., et al. 2023. Mol Cancer. 22: 12. PMID: 36650499
- S1P-S1PR3-RAS promotes the progression of S1PR3hi TAL1+ T-cell acute lymphoblastic leukemia that can be effectively inhibited by an S1PR3 antagonist. | Zhu, D., et al. 2023. Leukemia. 37: 1982-1993. PMID: 37591940
- TAL1 hijacks MYCN enhancer that induces MYCN expression and dependence on mevalonate pathway in T-cell acute lymphoblastic leukemia. | Tan, SH., et al. 2023. Leukemia. 37: 1969-1981. PMID: 37591943
- Regulatory mechanisms and context-dependent roles of TAL1 in T-cell acute lymphoblastic leukemia. | Ong, JZL., et al. 2024. Haematologica. 109: 1359-1372. PMID: 37855064
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAL1 Antibody (B-8) | sc-393288 | 200 µg/ml | $322.00 | |||
TAL1 Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-538182 | 200 µg Ab; 10 µg BP | $361.00 | |||
TAL1 Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-535744 | 200 µg Ab; 40 µg BP | $361.00 | |||
TAL1 Antibody (B-8) X | sc-393288 X | 200 µg/0.1 ml | $322.00 |