TAF II p105 Antibody (TAFAD26A): sc-81122

TAF II p105 Antibody (TAFAD26A) is a mouse monoclonal IgG1 antibody that detects TAF II p105 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-TAF II p105 antibody (TAFAD26A) is available as a non-conjugated format. TAF II p105, also known as TAF4B, is a crucial component of the TFIID complex, which is essential for the assembly of the preinitiation complex during transcription. TAF II p105 is primarily expressed in B cells and ovarian granulosa cells, where TAF II p105 plays a significant role in regulating gene expression. TAF II p105 interacts with the transcription factor OCBA/POU2AF1 to enhance B cell-specific octamer-dependent transcription, thereby influencing immune responses. TAF II p105 is vital for coactivating NF-kappaB, a key transcription factor involved in the regulation of anti-apoptotic genes such as TNFAIP3, which are critical for cell survival and proliferation. TAF II p105′s C-terminal histone-fold domain allows formation of heterodimers with TAF12/TAF II p20, facilitating the formation of transcriptional activating complexes. TAF II p105 is localized in the nucleus, with export to the cytoplasm occurring through a CRM1-independent pathway, highlighting TAF II p105′s importance in maintaining proper cellular function. Alternative splicing results in two isoforms of TAF II p105, further diversifying TAF II p105′s functional roles in transcriptional regulation.

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TAF II p105 Antibody (TAFAD26A) References:

1. Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.  |  Freiman, RN., et al. 2001. Science. 293: 2084-7. PMID: 11557891
2. A composite nuclear export signal in the TBP-associated factor TAFII105.  |  Rashevsky-Finkel, A., et al. 2001. J Biol Chem. 276: 44963-9. PMID: 11567023
3. Redundant role of tissue-selective TAF(II)105 in B lymphocytes.  |  Freiman, RN., et al. 2002. Mol Cell Biol. 22: 6564-72. PMID: 12192054
4. Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID.  |  Falender, AE., et al. 2005. Genes Dev. 19: 794-803. PMID: 15774719
5. TAF4b, a TBP associated factor, is required for oocyte development and function.  |  Falender, AE., et al. 2005. Dev Biol. 288: 405-19. PMID: 16289522
6. Cell-type-selective induction of c-jun by TAF4b directs ovarian-specific transcription networks.  |  Geles, KG., et al. 2006. Proc Natl Acad Sci U S A. 103: 2594-9. PMID: 16473943
7. Ovarian granulosa cell survival and proliferation requires the gonad-selective TFIID subunit TAF4b.  |  Voronina, E., et al. 2007. Dev Biol. 303: 715-26. PMID: 17207475
8. The TATA binding protein associated factor 4b (TAF4b) mediates FSH stimulation of the IGFBP-3 promoter in cultured porcine ovarian granulosa cells.  |  Ongeri, EM., et al. 2007. Mol Cell Endocrinol. 278: 29-35. PMID: 17888567
9. Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.  |  Dikstein, R., et al. 1996. Cell. 87: 137-46. PMID: 8858156

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TAF II p105 Antibody (TAFAD26A) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TAF II p105 Antibody (TAFAD26A) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TAF II p105 Antibody (TAFAD26A) Specifications

Alternate Product Name: TAF II p105

Product Clone Name: TAFAD26A

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: TAF II p105

Epitope Species: human

Product Reactivity/Detection: TAF II p105

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TAF II p105 Antibody (TAFAD26A): N/A