TACI Antibody (1A1): sc-32775
- TACI Antibody (1A1) is a rat monoclonal IgG2a, cited in 1 publications, provided at 200 µg/ml
- raised against rat basophilic leukemia mast cells transfected with TACI of human origin
- recommended for detection of TACI of human origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for neutralizing, sc-32775 L, 200 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TACI Antibody (1A1). This work is in progress.
QUICK LINKS
SEE ALSO...
TACI Antibody (1A1) is a rat monoclonal IgG2a antibody that detects TACI in human samples through immunofluorescence (IF) and flow cytometry (FCM) applications. TACI, or transmembrane activator and CAML-interactor, is a crucial member of the tumor necrosis factor receptor superfamily, primarily located on the surface of B cells and some T cells, where TACI plays a significant role in regulating immune responses. TACI′s strategic positioning on the cell membrane allows interaction with various ligands, including APRIL and BAFF, which are essential for B cell survival and differentiation. This interaction is vital for maintaining immune homeostasis and preventing autoimmune diseases, as TACI influences the proliferation and activation of B cells. Furthermore, TACI′s ability to modulate signaling pathways in response to these ligands underscores TACI′s importance in the immune system′s functionality. Anti-TACI antibody (1A1) is an invaluable tool for researchers studying B cell biology and the mechanisms underlying immune regulation, providing insights into potential therapeutic targets for immune-related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TACI Antibody (1A1) References:
- TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties. | Mackay, F. and Schneider, P. 2008. Cytokine Growth Factor Rev. 19: 263-76. PMID: 18514565
- Effect of TACI signaling on humoral immunity and autoimmune diseases. | Zhang, Y., et al. 2015. J Immunol Res. 2015: 247426. PMID: 25866827
- BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses. | Dickinson, GS., et al. 2015. Ann N Y Acad Sci. 1362: 57-67. PMID: 25962322
- TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection. | Allman, WR., et al. 2015. Proc Natl Acad Sci U S A. 112: E4094-103. PMID: 26170307
- TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis. | Liu, L., et al. 2018. Diabetes. 67: 1589-1603. PMID: 29871859
- TACI Isoforms Regulate Ligand Binding and Receptor Function. | Garcia-Carmona, Y., et al. 2018. Front Immunol. 9: 2125. PMID: 30333819
- Telitacicept, a novel humanized, recombinant TACI-Fc fusion protein, for the treatment of systemic lupus erythematosus. | Fan, Y., et al. 2022. Drugs Today (Barc). 58: 23-32. PMID: 35107091
- TACI and endogenous APRIL in B cell maturation. | Garcia-Carmona, Y., et al. 2023. Clin Immunol. 253: 109689. PMID: 37422057
- Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma. | Larson, RC., et al. 2023. Nat Commun. 14: 7509. PMID: 37980341
- Unique and redundant roles of mouse BCMA, TACI, BAFF, APRIL, and IL-6 in supporting antibody-producing cells in different tissues. | Eslami, M., et al. 2024. Proc Natl Acad Sci U S A. 121: e2404309121. PMID: 38990948
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TACI Antibody (1A1) | sc-32775 | 200 µg/ml | $322.00 | |||
TACI Antibody (1A1) FITC | sc-32775 FITC | 200 µg/ml | $336.00 | |||
TACI Antibody (1A1) L | sc-32775 L | 200 µg/0.1 ml | $322.00 | |||
TACI Antibody (1A1) PE | sc-32775 PE | 200 µg/ml | $349.00 |