TAB2 Antibody (E-5): sc-398188

TAB2 Antibody (E-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects TAB2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TAB2 Antibody (E-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TAB2 plays a crucial role in cellular signaling pathways, particularly in transforming growth factor-beta (TGF-β) signaling cascade. TAB2 acts as an essential mediator that interacts with mitogen-activated protein kinase kinase kinase (MAPKKK) TAK1, facilitating activation of downstream signaling pathways in response to various stimuli. This interaction regulates inflammatory responses and cellular stress, as TAB2 helps translocate TAK1 complex from membrane to cytosol upon pro-inflammatory signals, promoting TAK1 activation. TAB2′s ability to form complexes with other binding proteins, such as TAB1 and TAB3, further underscores TAB2′s importance in modulating activity of key transcription factors like NF-kB and AP-1, which are critical for immune responses and cellular homeostasis. With versatile applications and significant role in cellular signaling, anti-TAB2 antibody (E-5) serves as an invaluable tool for researchers studying intricacies of MAPK signaling pathways and their implications in various biological processes.

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TAB2 Antibody (E-5) References:

1. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.  |  Ge, B., et al. 2002. Science. 295: 1291-4. PMID: 11847341
2. Some issues in the consideration of non-Western and Western folk practices as epidemiologic data.  |  Pfifferling, JH. 1975. Soc Sci Med (1967). 9: 655-8. PMID: 1224229
3. Identification of a human NF-kappaB-activating protein, TAB3.  |  Jin, G., et al. 2004. Proc Natl Acad Sci U S A. 101: 2028-33. PMID: 14766965
4. The SUMOylation of TAB2 mediated by TRIM60 inhibits MAPK/NF-κB activation and the innate immune response.  |  Gu, Z., et al. 2021. Cell Mol Immunol. 18: 1981-1994. PMID: 33184450
5. TAB2 deletions and variants cause a highly recognisable syndrome with mitral valve disease, cardiomyopathy, short stature and hypermobility.  |  Engwerda, A., et al. 2021. Eur J Hum Genet. 29: 1669-1676. PMID: 34456334
6. TAB2 variants cause cardiovascular heart disease, connective tissue disorder, and developmental delay.  |  Hanson, J., et al. 2022. Clin Genet. 101: 214-220. PMID: 34741306
7. TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis.  |  Yin, H., et al. 2022. J Clin Invest. 132: PMID: 34990405
8. E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2.  |  Zhang, J., et al. 2023. Cell Death Differ. 30: 966-978. PMID: 36681779
9. Tripartite motif 38 alleviates the pathological process of NAFLD-NASH by promoting TAB2 degradation.  |  Yao, X., et al. 2023. J Lipid Res. 64: 100382. PMID: 37116711
10. USP25 Inhibits Neuroinflammatory Responses After Cerebral Ischemic Stroke by Deubiquitinating TAB2.  |  Li, Z., et al. 2023. Adv Sci (Weinh). 10: e2301641. PMID: 37587766
11. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.  |  Yamaguchi, K., et al. 1995. Science. 270: 2008-11. PMID: 8533096
12. TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.  |  Shibuya, H., et al. 1996. Science. 272: 1179-82. PMID: 8638164

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TAB2 Antibody (E-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TAB2 Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TAB2 Antibody (E-5) Specifications

Alternate Product Name: TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 48-73

Epitope Target: TAB2

Epitope Species: human

Product Reactivity/Detection: TAB2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TAB2 Antibody (E-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin