SYT Antibody (A-10): sc-365170

SYT Antibody (A-10) is a mouse monoclonal IgG2a antibody that detects SYT in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SYT, or synovial translocation protein, plays a crucial role as a transcriptional coactivator, particularly in synovial sarcoma, where SYT is involved in forming oncogenic fusion proteins with SSX family members. These fusions, specifically SYT-SSX1 and SYT-SSX2, result from the t(x;18) chromosomal translocation and lead to potent transcriptional activators that drive tumorigenesis. The presence of these chimeric proteins is a hallmark of synovial sarcomas, which account for a significant percentage of soft tissue sarcomas and exhibit distinct histological features. Understanding SYT function and interactions with SSX proteins is vital, as this knowledge not only aids in synovial sarcoma diagnosis but also provides insights into potential therapeutic targets. Nuclear localization of SYT underscores SYT′s importance in regulating gene expression, making anti-SYT antibody (A-10) an essential tool for researchers studying molecular mechanisms underlying synovial sarcoma and related malignancies.

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SYT Antibody (A-10) References:

1. Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression.  |  Brodin, B., et al. 2001. Gene. 268: 173-82. PMID: 11368913
2. Fusions of the SYT and SSX genes in synovial sarcoma.  |  Ladanyi, M. 2001. Oncogene. 20: 5755-62. PMID: 11607825
3. Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas.  |  Yang, K., et al. 2002. Oncogene. 21: 4181-90. PMID: 12037676
4. The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling.  |  Saito, T. 2013. Int J Clin Exp Pathol. 6: 2272-9. PMID: 24228088
5. Role of the Sec22b-E-Syt complex in neurite growth and ramification.  |  Gallo, A., et al. 2020. J Cell Sci. 133: PMID: 32843578
6. Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma.  |  Jin, H., et al. 2020. Future Oncol. 16: 2809-2819. PMID: 33052751
7. The role of SYT-SSX fusion gene in tumorigenesis of synovial sarcoma.  |  Feng, X., et al. 2021. Pathol Res Pract. 222: 153416. PMID: 33848939
8. SYT-SSX1 enhances the invasiveness and maintains stem-like cell properties in synovial sarcoma via induction of TGF-β1/Smad signaling.  |  Qi, Y., et al. 2022. BMC Cancer. 22: 166. PMID: 35151264
9. Altered cognition and anxiety in adolescent offspring whose mothers underwent different-pattern maternal sleep deprivation, and cognition link to hippocampal expressions of Bdnf and Syt-1.  |  Wei, RM., et al. 2022. Front Behav Neurosci. 16: 1066725. PMID: 36570704
10. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma.  |  Kawai, A., et al. 1998. N Engl J Med. 338: 153-60. PMID: 9428816

The preferred SYT antibody is SYT Antibody (D-3): sc-390615.