SYP/Synaptophysin Antibody (SY38): sc-58304

SYP Antibody (SY38) is a mouse monoclonal IgG1 antibody that detects synaptophysin (SYP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Synaptophysin (SYP) is an integral membrane protein predominantly located in synaptic vesicles of neurons and endocrine cells, playing a crucial role in neurotransmitter release and synaptic transmission. Anti-SYP antibody (SY38) recognizes SYP in synaptic vesicles, which is vital for proper neuronal communication, as SYP participates in vesicle fusion with the plasma membrane, a process essential for neurotransmitter release into the synaptic cleft. SYP forms hexameric complexes, which may function similarly to gap junctions, facilitating intercellular communication. SYP interacts with membrane cholesterol, which is important for vesicle formation and stability. SYP forms complexes with synaptobrevin (VAMP), which are upregulated during neuronal development, indicating a role in preparing synaptic machinery for effective neurotransmission. While the synaptophysin-synaptobrevin complex is not essential for exocytosis, this complex serves as a synaptobrevin reservoir, ensuring sufficient levels for neurotransmitter release. SYP monoclonal antibody (SY38) is an invaluable tool for researchers studying synaptic function and molecular mechanisms underlying neurotransmission.

The preferred SYP/Synaptophysin antibody is SYP/Synaptophysin Antibody (D-4): sc-17750.