Syntaxin 5 Antibody (B-8): sc-365124

Syntaxin 5 Antibody (B-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Syntaxin 5 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Syntaxin 5 antibody (B-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Syntaxin 5 plays a crucial role in the vesicular transport system, which is vital for the proper functioning and survival of eukaryotic cells. Syntaxin 5 is primarily located in the cis-Golgi, where Syntaxin 5 facilitates the fusion of vesicles with target membranes, a process essential for the transport of proteins and lipids within the cell. The unique structure of Syntaxin 5, characterized by a short transmembrane domain, ensures localization to the cis-Golgi, allowing interaction with other SNARE proteins to form stable complexes that drive membrane fusion. This interaction is critical for maintaining cellular homeostasis and ensuring proteins are correctly sorted and delivered to their destinations. Syntaxin 5 also associates with p97, which is important for regulating the assembly of the transitional endoplasmic reticulum, further underscoring significance in intracellular transport mechanisms.

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Syntaxin 5 Antibody (B-8) References:

1. Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5.  |  Watson, RT. and Pessin, JE. 2001. Am J Physiol Cell Physiol. 281: C215-23. PMID: 11401844
2. GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.  |  Xu, Y., et al. 2002. Mol Biol Cell. 13: 3493-507. PMID: 12388752
3. Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle.  |  Huang, S., et al. 2016. Dev Cell. 38: 73-85. PMID: 27404360
4. Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress.  |  Babazadeh, R., et al. 2019. Cell Rep. 28: 2096-2110.e8. PMID: 31433985
5. Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture.  |  Kat, M., et al. 2022. Haematologica. 107: 1827-1839. PMID: 35081689
6. Syntaxin 5-dependent phosphorylation of the small heat shock protein Hsp42 and its role in protein quality control.  |  Ahmadpour, D., et al. 2023. FEBS J. 290: 4744-4761. PMID: 37306264
7. Syntaxin-5's flexibility in SNARE pairing supports Golgi functions.  |  D'Souza, Z., et al. 2023. Traffic. 24: 355-379. PMID: 37340984
8. The syntaxin family of vesicular transport receptors.  |  Bennett, MK., et al. 1993. Cell. 74: 863-73. PMID: 7690687
9. Syntaxin 5 regulates endoplasmic reticulum to Golgi transport.  |  Dascher, C., et al. 1994. J Biol Chem. 269: 29363-6. PMID: 7961911

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Syntaxin 5 Antibody (B-8) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-Syntaxin 5 Antibody (B-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Syntaxin 5 Antibody (B-8) Specifications

Alternate Product Name: Syntaxin 5

Product Clone Name: B-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-301

Epitope Target: Syntaxin 5

Epitope Species: human

Product Reactivity/Detection: Syntaxin 5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for Syntaxin 5 Antibody (B-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin