Syntaxin 4 Antibody (QQ-17): sc-101301

Syntaxin 4 Antibody (QQ-17) is a mouse monoclonal IgG1 kappa light chain antibody that detects Syntaxin 4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Syntaxin 4 antibody (QQ-17) is available as the non-conjugated format. Syntaxin 4 plays a pivotal role in regulating vesicular transport, which is essential for proper functioning of eukaryotic cells. Syntaxin 4 is primarily located on the plasma membrane and is involved in the fusion of insulin-containing vesicles with the membrane, a critical step for insulin-stimulated glucose uptake in skeletal muscle. This localization is vital because any disruption in Syntaxin 4 function can lead to impaired glucose metabolism, contributing to conditions such as insulin resistance and type 2 diabetes. Syntaxin 4′s structure includes a carboxy-terminal hydrophobic domain that anchors to the membrane, facilitating interaction with other proteins in the SNARE complex, which is crucial for vesicle fusion. Syntaxin 4 (QQ-17) antibody is an invaluable tool for researchers studying the mechanisms of vesicular transport and implications in metabolic diseases, providing insights into molecular pathways that govern insulin signaling and glucose homeostasis.

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Syntaxin 4 Antibody (QQ-17) References:

1. Deployment of membrane fusion protein domains during fusion.  |  Bentz, J. and Mittal, A. 2000. Cell Biol Int. 24: 819-38. PMID: 11067767
2. Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance.  |  Yang, C., et al. 2001. J Clin Invest. 107: 1311-8. PMID: 11375421
3. Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5.  |  Watson, RT. and Pessin, JE. 2001. Am J Physiol Cell Physiol. 281: C215-23. PMID: 11401844
4. Syntaxin 4 is concentrated on plasma membrane of astrocytes.  |  Tao-Cheng, JH., et al. 2015. Neuroscience. 286: 264-71. PMID: 25485479
5. Syntaxin 4 mediates endosome recycling for lytic granule exocytosis in cytotoxic T-lymphocytes.  |  Spessott, WA., et al. 2017. Traffic. 18: 442-452. PMID: 28471021
6. Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice.  |  Oh, E., et al. 2021. Diabetes. 70: 2837-2849. PMID: 34556496
7. Syntaxin 4 - protective in β-cells in T1DM?  |  Starling, S. 2021. Nat Rev Endocrinol. 17: 708. PMID: 34663930
8. Knockout of syntaxin-4 in 3T3-L1 adipocytes reveals new insight into GLUT4 trafficking and adiponectin secretion.  |  Black, HL., et al. 2022. J Cell Sci. 135: PMID: 34859814
9. Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation.  |  Gigon, L., et al. 2023. Front Immunol. 14: 1272699. PMID: 37885878
10. The syntaxin family of vesicular transport receptors.  |  Bennett, MK., et al. 1993. Cell. 74: 863-73. PMID: 7690687
11. A v-SNARE implicated in intra-Golgi transport.  |  Nagahama, M., et al. 1996. J Cell Biol. 133: 507-16. PMID: 8636227
12. A SNARE involved in protein transport through the Golgi apparatus.  |  Lowe, SL., et al. 1997. Nature. 389: 881-4. PMID: 9349823

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Syntaxin 4 Antibody (QQ-17) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Syntaxin 4 Antibody (QQ-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Syntaxin 4 Antibody (QQ-17) Specifications

Alternate Product Name: Syntaxin 4

Product Clone Name: QQ-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 19-120

Epitope Target: Syntaxin 4

Epitope Species: human

Product Reactivity/Detection: syntaxin 4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Syntaxin 4 Antibody (QQ-17): N/A