Syntaxin 2 Antibody (A-12): sc-514642
- Syntaxin 2 Antibody (A-12) is a mouse monoclonal IgG1 κ Syntaxin 2 antibody provided at 200 µg/ml
- raised against amino acids 210-252 mapping near the C-terminus of Syntaxin 2 of human origin
- Syntaxin 2 Antibody (A-12) is recommended for detection of Syntaxin 2 of human origin by WB, IP, IF and ELISA
- Anti-Syntaxin 2 Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Syntaxin 2 Antibody (A-12) for WB applications. These reagents are now offered in bundles with Syntaxin 2 Antibody (A-12) (see ordering information below).
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Syntaxin 2 Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Syntaxin 2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Syntaxin 2 antibody (A-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Syntaxin 2 plays a crucial role in vesicular transport, which is vital for proper functioning and survival of eukaryotic cells. Syntaxin 2 belongs to the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family, specifically functioning as a target SNARE (t-SNARE) that localizes to the apical plasma membrane and intracellular vesicular structures. Syntaxin 2 interaction with vesicle-associated SNAREs (v-SNAREs) is essential for forming stable SNARE complexes, which facilitate vesicle fusion with target membranes. This process is particularly important in regulated secretion, such as surfactant release in lung epithelial cells, where Syntaxin 2 works with SNAP-23. Proper localization and function of Syntaxin 2 are critical for maintaining cellular homeostasis and ensuring effective cell-to-cell communication, making Syntaxin 2 a significant target for cellular biology research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Syntaxin 2 Antibody (A-12) References:
- Syntaxin 2 and SNAP-23 are required for regulated surfactant secretion. | Abonyo, BO., et al. 2004. Biochemistry. 43: 3499-506. PMID: 15035620
- The syntaxin family of vesicular transport receptors. | Bennett, MK., et al. 1993. Cell. 74: 863-73. PMID: 7690687
- Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. | Edelmann, L., et al. 1995. EMBO J. 14: 224-31. PMID: 7835333
- Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site. | McMahon, HT. and Südhof, TC. 1995. J Biol Chem. 270: 2213-7. PMID: 7836452
- Exocytosis relating proteins in the nervous system. | Yamaguchi, K. and Akagawa, K. 1994. Neurosci Res. 20: 289-92. PMID: 7870381
- Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. | Hayashi, T., et al. 1994. EMBO J. 13: 5051-61. PMID: 7957071
- A role for synaptotagmin (p65) in regulated exocytosis. | Elferink, LA., et al. 1993. Cell. 72: 153-9. PMID: 8422678
- Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. | Barnard, RJ., et al. 1997. J Cell Biol. 139: 875-83. PMID: 9362506
- Structural organization of the synaptic exocytosis core complex. | Lin, RC. and Scheller, RH. 1997. Neuron. 19: 1087-94. PMID: 9390521
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syntaxin 2 Antibody (A-12) | sc-514642 | 200 µg/ml | $316.00 | |||
Syntaxin 2 Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-527924 | 200 µg Ab; 10 µg BP | $354.00 | |||
Syntaxin 2 Antibody (A-12): m-IgG1 BP-HRP Bundle | sc-533297 | 200 µg Ab; 20 µg BP | $354.00 | |||
Syntaxin 2 Antibody (A-12) AC | sc-514642 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Syntaxin 2 Antibody (A-12) HRP | sc-514642 HRP | 200 µg/ml | $316.00 | |||
Syntaxin 2 Antibody (A-12) FITC | sc-514642 FITC | 200 µg/ml | $330.00 | |||
Syntaxin 2 Antibody (A-12) PE | sc-514642 PE | 200 µg/ml | $343.00 | |||
Syntaxin 2 Antibody (A-12) Alexa Fluor® 488 | sc-514642 AF488 | 200 µg/ml | $357.00 | |||
Syntaxin 2 Antibody (A-12) Alexa Fluor® 546 | sc-514642 AF546 | 200 µg/ml | $357.00 | |||
Syntaxin 2 Antibody (A-12) Alexa Fluor® 594 | sc-514642 AF594 | 200 µg/ml | $357.00 | |||
Syntaxin 2 Antibody (A-12) Alexa Fluor® 647 | sc-514642 AF647 | 200 µg/ml | $357.00 | |||
Syntaxin 2 Antibody (A-12) Alexa Fluor® 680 | sc-514642 AF680 | 200 µg/ml | $357.00 | |||
Syntaxin 2 Antibody (A-12) Alexa Fluor® 790 | sc-514642 AF790 | 200 µg/ml | $357.00 |