Syntaxin 1 Antibody (C-5): sc-17836
- Syntaxin 1 Antibody (C-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 3-225 of Syntaxin 1A of human origin
- recommended for detection of Syntaxin 1A and Syntaxin 1B of mouse, rat and human origin by WB, IP, IF and ELISA; may cross-react with other Syntaxin family members
- See Syntaxin 1 (HPC-1): sc-12736 for Syntaxin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Syntaxin 1 Antibody (C-5) for WB applications. These reagents are now offered in bundles with Syntaxin 1 Antibody (C-5) (see ordering information below).
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Syntaxin 1 Antibody (C-5) is a mouse monoclonal IgG1 antibody that detects Syntaxin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Syntaxin 1 plays a crucial role in vesicular transport, which is essential for eukaryotic cell survival. Syntaxin 1 is primarily located in the plasma membrane and serves as a key component of the SNARE complex, which facilitates synaptic vesicle fusion with the plasma membrane for neurotransmitter release. Proper functioning of Syntaxin 1 ensures accurate targeting and fusion of synaptic vesicles with the membrane, influencing synaptic efficacy and plasticity. Dysregulation of Syntaxin 1 can lead to various neurological disorders, highlighting Syntaxin 1′s importance in maintaining cellular communication and overall brain function. Anti-Syntaxin 1 antibody (C-5) serves as an invaluable tool for researchers studying synaptic mechanisms and related pathologies, providing reliable detection and characterization of this essential protein.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Syntaxin 1 Antibody (C-5) References:
- Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion. | Zhou, P., et al. 2013. EMBO J. 32: 159-71. PMID: 23188083
- Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex. | Dawidowski, D. and Cafiso, DS. 2016. Structure. 24: 392-400. PMID: 26876096
- Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly. | Lee, S., et al. 2020. Sci Rep. 10: 11623. PMID: 32669573
- Syntaxin-1 and Insulinoma-Associated Protein 1 Expression in Breast Neoplasms with Neuroendocrine Features. | Turkevi-Nagy, S., et al. 2021. Pathol Oncol Res. 27: 1610039. PMID: 34764822
- Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex. | Gong, J., et al. 2021. Front Mol Neurosci. 14: 785696. PMID: 35002621
- SNARE assembly enlightened by cryo-EM structures of a synaptobrevin-Munc18-1-syntaxin-1 complex. | Stepien, KP., et al. 2022. Sci Adv. 8: eabo5272. PMID: 35731863
- An Atypical, Staged Cell Death Pathway Induced by Depletion of SNARE-Proteins MUNC18-1 or Syntaxin-1. | Feringa, FM., et al. 2023. J Neurosci. 43: 347-358. PMID: 36517239
- Syntaxin 1 Ser14 phosphorylation is required for nonvesicular dopamine release. | Shekar, A., et al. 2023. Sci Adv. 9: eadd8417. PMID: 36630507
- Functional regulation of syntaxin-1: An underlying mechanism mediating exocytosis in neuroendocrine cells. | Yang, X., et al. 2023. Front Endocrinol (Lausanne). 14: 1096365. PMID: 36742381
- Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion. | Martínez-Mármol, R., et al. 2023. Front Mol Neurosci. 16: 1253954. PMID: 37829513
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syntaxin 1 Antibody (C-5) | sc-17836 | 200 µg/ml | $322.00 | |||
Syntaxin 1 Antibody (C-5): m-IgG Fc BP-HRP Bundle | sc-538899 | 200 µg Ab; 10 µg BP | $361.00 | |||
Syntaxin 1 Antibody (C-5): m-IgG1 BP-HRP Bundle | sc-541132 | 200 µg Ab; 20 µg BP | $361.00 |