Synaptotagmin I Antibody (15): sc-136480

Synaptotagmin I Antibody (15) is a mouse monoclonal IgG1 kappa light chain antibody that detects Synaptotagmin I protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Synaptotagmin I antibody (15) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). Synaptotagmin I is a crucial member of the synaptotagmin family, which consists of integral membrane proteins that play a vital role in regulating exocytosis and endocytosis, particularly in neurotransmitter release from synaptic vesicles. Synaptotagmin I (15) monoclonal antibody localizes to presynaptic terminals of neurons, where Synaptotagmin I acts as a calcium sensor triggering neurotransmitter release upon calcium influx. This function is essential for synaptic transmission and communication between neurons, making Synaptotagmin I a key player in nervous system functionality. Synaptotagmin I also interacts with various proteins, including SNARE proteins, which are critical for synaptic vesicle fusion with presynaptic membrane. Understanding Synaptotagmin I interactions and mechanisms is important for elucidating processes underlying synaptic plasticity and neurotransmission, as well as their implications in neurological disorders.

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Synaptotagmin I Antibody (15) References:

1. Analysis of synaptotagmin I-IV messenger RNA expression and developmental regulation in the rat hypothalamus and pituitary.  |  Xi, D., et al. 1999. Neuroscience. 88: 425-35. PMID: 10197764
2. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity.  |  Ferguson, GD., et al. 2000. J Biol Chem. 275: 36920-6. PMID: 10938284
3. Synaptotagmin I functions as a calcium regulator of release probability.  |  Fernández-Chacón, R., et al. 2001. Nature. 410: 41-9. PMID: 11242035
4. Synaptotagmin I increases the probability of vesicle fusion at low [Ca2+] in pituitary cells.  |  Kreft, M., et al. 2003. Am J Physiol Cell Physiol. 284: C547-54. PMID: 12388083
5. Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.  |  Yoshihara, M. and Littleton, JT. 2002. Neuron. 36: 897-908. PMID: 12467593
6. Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo.  |  Poskanzer, KE., et al. 2003. Nature. 426: 559-63. PMID: 14634669
7. Synaptotagmin I synchronizes transmitter release in mouse hippocampal neurons.  |  Nishiki, T. and Augustine, GJ. 2004. J Neurosci. 24: 6127-32. PMID: 15240804
8. Presynaptic trafficking of synaptotagmin I is regulated by protein palmitoylation.  |  Kang, R., et al. 2004. J Biol Chem. 279: 50524-36. PMID: 15355980
9. Pull-down combined with proteomic strategy reveals functional diversity of synaptotagmin I.  |  Guo, T., et al. 2017. PeerJ. 5: e2973. PMID: 28194317
10. Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.  |  Li, C., et al. 1995. Nature. 375: 594-9. PMID: 7791877
11. A third synaptotagmin gene, Syt3, in the mouse.  |  Hilbush, BS. and Morgan, JI. 1994. Proc Natl Acad Sci U S A. 91: 8195-9. PMID: 8058779
12. Expression of synaptotagmin VIII in rat kidney.  |  Kishore, BK., et al. 1998. Am J Physiol. 275: F131-42. PMID: 9689015

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Synaptotagmin I Antibody (15) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-Synaptotagmin I Antibody (15) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Synaptotagmin I Antibody (15) Specifications

Alternate Product Name: Synaptotagmin I

Product Clone Name: 15

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 250-259

Epitope Target: Synaptotagmin I

Epitope Species: human

Product Reactivity/Detection: Synaptotagmin I

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for Synaptotagmin I Antibody (15): AC: Agarose, HRP: Horseradish Peroxidase