Synapsin Ia/b Antibody (D-8): sc-390867
- Synapsin Ia/b Antibody (D-8) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 651-665 near the C-terminus of Synapsin Ia of human origin
- recommended for detection of Synapsin Ia and Synapsin Ib of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Synapsin Ia/b Antibody (D-8). This work is in progress.
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Synapsin Ia/b Antibody (D-8) is a mouse monoclonal IgM antibody that detects Synapsin Ia/b in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Synapsin Ia/b plays a crucial role in regulating synaptic vesicle exocytosis, which is essential for neurotransmitter release and communication between neurons. Synapsin Ia/b is primarily located in presynaptic terminals of neurons, where anti-Synapsin Ia/b antibody (D-8) can detect its association with synaptic vesicles and involvement in clustering these vesicles near the active zone, facilitating efficient neurotransmission. Proper functioning of Synapsin Ia/b is vital for synaptic plasticity, learning, and memory, as Synapsin Ia/b influences neurotransmitter availability during synaptic transmission. Post-translational modifications, including phosphorylation, can modulate Synapsin Ia/b activity and interactions with other proteins, further underscoring Synapsin Ia/b′s importance in synaptic function and neuronal signaling. Synapsin Ia/b monoclonal antibody (D-8) serves as an invaluable tool for researchers studying synaptic mechanisms and neurobiology, providing insights into complex processes underlying neuronal communication and plasticity.
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Synapsin Ia/b Antibody (D-8) References:
- Synapsin III: role in neuronal plasticity and disease. | Porton, B., et al. 2011. Semin Cell Dev Biol. 22: 416-24. PMID: 21827867
- Maggot learning and Synapsin function. | Diegelmann, S., et al. 2013. J Exp Biol. 216: 939-51. PMID: 23447663
- Synapsin I: a regulated synaptic vesicle organizing protein. | Steiner, JP., et al. 1987. Brain Res Bull. 18: 777-85. PMID: 3113674
- Synapsin Ia, synapsin Ib, protein IIIa, and protein IIIb, four related synaptic vesicle-associated phosphoproteins, share regional and cellular localization in rat brain. | Walaas, SI., et al. 1988. J Neurochem. 51: 1214-20. PMID: 3138387
- Cystatin C promotes cognitive dysfunction in rats with cerebral microbleeds by inhibiting the ERK/synapsin Ia/Ib pathway. | Yu, G., et al. 2020. Exp Ther Med. 19: 2282-2290. PMID: 32104295
- A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease. | Meng, L., et al. 2022. Aging Cell. 21: e13619. PMID: 35443102
- Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates. | Park, D., et al. 2023. Nat Commun. 14: 455. PMID: 36709207
- Maternal synapsin autoantibodies are associated with neurodevelopmental delay. | Bünger, I., et al. 2023. Front Immunol. 14: 1101087. PMID: 36742338
- Synapsin autoantibodies during pregnancy are associated with fetal abnormalities. | Bünger, I., et al. 2023. Brain Behav Immun Health. 33: 100678. PMID: 37692096
- Synapsin E-domain is essential for α-synuclein function. | Stavsky, A., et al. 2024. Elife. 12: PMID: 38713200
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Synapsin Ia/b Antibody (D-8) | sc-390867 | 200 µg/ml | $322.00 | |||
Synapsin Ia/b (D-8) Neutralizing Peptide | sc-390867 P | 100 µg/0.5 ml | $69.00 |