Synapsin Ia/b Antibody (B-12): sc-398846
- Synapsin Ia/b Antibody (B-12) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 667-686 at the C-terminus of Synapsin Ia/b of human origin
- recommended for detection of Synapsin Ia/b of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for Synapsin Ia/b Antibody (B-12) for WB applications. This reagent is now offered in a bundle with Synapsin Ia/b Antibody (B-12) (see ordering information below).
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Synapsin Ia/b Antibody (B-12) is a mouse monoclonal IgG3 antibody that detects Synapsin Ia/b in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Synapsin Ia/b plays a crucial role in regulating synaptic vesicle exocytosis, which is essential for neurotransmitter release and communication between neurons. Synapsin Ia/b is primarily located in presynaptic terminals of neurons, where anti-Synapsin Ia/b antibody (B-12) can detect its association with synaptic vesicles and role in synaptogenesis and synaptic plasticity. Synapsin Ia/b presence in these regions is vital for maintaining synaptic function and ensuring efficient neurotransmission, which is critical for processes such as learning and memory. Synapsin Ia/b undergoes alternative splicing, resulting in distinct isoforms that may have unique regulatory roles in synaptic function. Synapsin Ia/b interaction with other proteins involved in synaptic vesicle trafficking further underscores its importance in neuronal communication. Synapsin Ia/b monoclonal antibody (B-12) offers robust reactivity and versatility in various applications, making this reagent invaluable for researchers studying synaptic mechanisms and neurobiology.
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Synapsin Ia/b Antibody (B-12) References:
- Neuronal compartments and axonal transport of synapsin I. | Paggi, P. and Petrucci, TC. 1992. Mol Neurobiol. 6: 239-51. PMID: 1282334
- Functional roles of synapsin: lessons from invertebrates. | Humeau, Y., et al. 2011. Semin Cell Dev Biol. 22: 425-33. PMID: 21843652
- Epigenetic regulation of synapsin genes in mood disorders. | Cruceanu, C., et al. 2013. Neuropsychopharmacology. 38: 239-41. PMID: 23147482
- SORLA regulates calpain-dependent degradation of synapsin. | Hartl, D., et al. 2016. Alzheimers Dement. 12: 952-963. PMID: 27021222
- Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons. | Song, SH. and Augustine, GJ. 2016. J Neurosci. 36: 6742-57. PMID: 27335405
- Synapsin-antibodies in psychiatric and neurological disorders: Prevalence and clinical findings. | Höltje, M., et al. 2017. Brain Behav Immun. 66: 125-134. PMID: 28733081
- Synapsin I: a synaptic vesicle-associated neuronal phosphoprotein. | De Camilli, P. and Greengard, P. 1986. Biochem Pharmacol. 35: 4349-57. PMID: 2878666
- Synapsin 1 promotes Aβ generation via BACE1 modulation. | Maesako, M., et al. 2019. PLoS One. 14: e0226368. PMID: 31830091
- Synapsin condensation is governed by sequence-encoded molecular grammars. | Hoffmann, C., et al. 2024. bioRxiv.. PMID: 39131319
- Synapsin I, synapsin II, and synaptophysin: marker proteins of synaptic vesicles. | Thiel, G. 1993. Brain Pathol. 3: 87-95. PMID: 7903586
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Synapsin Ia/b Antibody (B-12) | sc-398846 | 200 µg/ml | $316.00 | |||
Synapsin Ia/b Antibody (B-12): m-IgG3 BP-HRP Bundle | sc-550514 | 200 µg Ab; 40 µg BP | $354.00 |