Synapsin Ia/b Antibody (B-11): sc-376622
- Synapsin Ia/b Antibody (B-11) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-29 at the N-terminus of Synapsin Ia/b of human origin
- recommended for detection of a broad range of synapsin family memebers of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG2a BP-HRP is the preferred secondary detection reagent for Synapsin Ia/b Antibody (B-11) for WB applications. This reagent is now offered in a bundle with Synapsin Ia/b Antibody (B-11) (see ordering information below).
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Synapsin Ia/b Antibody (B-11) is a mouse monoclonal IgG2a antibody that detects Synapsin Ia/b in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Synapsin Ia/b plays a crucial role in regulating synaptic vesicle exocytosis, which is essential for neurotransmitter release and communication between neurons. Synapsin Ia/b is primarily located in presynaptic terminals of neurons, where anti-Synapsin Ia/b antibody (B-11) can detect its association with synaptic vesicles and involvement in clustering these vesicles near the active zone, facilitating efficient neurotransmission. Proper functioning of Synapsin Ia/b is vital for synaptic plasticity, learning, and memory, as Synapsin Ia/b influences neurotransmitter availability during synaptic transmission. Post-translational modifications, including phosphorylation, can modulate Synapsin Ia/b activity and interactions with other proteins, further underscoring its importance in synaptic function and neuronal signaling. Synapsin Ia/b monoclonal antibody (B-11) serves as an invaluable tool for researchers studying synaptic mechanisms and neurobiology, providing insights into complex processes underlying neuronal communication and plasticity.
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Synapsin Ia/b Antibody (B-11) References:
- The enhancement of stress-related memory by glucocorticoids depends on synapsin-Ia/Ib. | Revest, JM., et al. 2010. Mol Psychiatry. 15: 1125, 1140-51. PMID: 20368707
- Monocular deprivation delays the dynamic changes of phosphorylated synapsin Ia/b at site-1 in contralateral visual cortex of juvenile mice. | Fu, T., et al. 2015. Neurochem Res. 40: 524-30. PMID: 25576091
- Synapsin Isoforms and Synaptic Vesicle Trafficking. | Song, SH. and Augustine, GJ. 2015. Mol Cells. 38: 936-40. PMID: 26627875
- cPKCγ alleviates ischemic injury through modulating synapsin Ia/b phosphorylation in neurons of mice. | Zhang, N., et al. 2018. Brain Res Bull. 142: 156-162. PMID: 30016727
- Modulation of cPKCγ on Synapsin-Ia/b-Specific Phosphorylation Sites in the Developing Visual Cortex of Mice. | Fu, T., et al. 2019. Invest Ophthalmol Vis Sci. 60: 2676-2684. PMID: 31242289
- The Phosphoprotein Synapsin Ia Regulates the Kinetics of Dense-Core Vesicle Release. | Yang, HJ., et al. 2021. J Neurosci. 41: 2828-2841. PMID: 33632727
- Synapsin Condensates Recruit alpha-Synuclein. | Hoffmann, C., et al. 2021. J Mol Biol. 433: 166961. PMID: 33774037
- Different mechanisms of synapsin-induced vesicle clustering at inhibitory and excitatory synapses. | Song, SH. and Augustine, GJ. 2023. Cell Rep. 42: 113004. PMID: 37597184
- Synapsin condensation controls synaptic vesicle sequestering and dynamics. | Hoffmann, C., et al. 2023. Nat Commun. 14: 6730. PMID: 37872159
- The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice. | Shen, XY., et al. 2024. J Clin Invest. 134: PMID: 38175724
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Synapsin Ia/b Antibody (B-11) | sc-376622 | 200 µg/ml | $322.00 | |||
Synapsin Ia/b Antibody (B-11): m-IgG2a BP-HRP Bundle | sc-546062 | 200 µg Ab; 10 µg BP | $361.00 | |||
Synapsin Ia/b (B-11) Neutralizing Peptide | sc-376622 P | 100 µg/0.5 ml | $69.00 |