Synapsin Ia/b Antibody (A-8): sc-376623

Synapsin Ia/b Antibody (A-8) is a mouse monoclonal IgM antibody that detects Synapsin Ia/b of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Synapsin Ia/b antibody (A-8) is available as a non-conjugated format. Synapsins are critical synaptic vesicle-associated phosphoproteins that play a vital role in regulating synaptic vesicle exocytosis and are implicated in synaptogenesis, which is essential for proper neuronal communication and plasticity. Synapsin Ia/b is primarily located in presynaptic terminals of neurons, where Synapsin Ia/b facilitates clustering of synaptic vesicles and their release in response to calcium influx. This localization ensures efficient neurotransmitter release during synaptic transmission, influencing synaptic strength and plasticity. Additionally, Synapsin Ia/b interaction with other proteins, such as actin and various signaling molecules, underscores Synapsin Ia/b importance in maintaining synaptic integrity and function. Anti-Synapsin Ia/b antibody (A-8) detection across multiple species makes anti-Synapsin Ia/b antibody (A-8) valuable for studying synaptic mechanisms in various models of neurological function and disease.

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Synapsin Ia/b Antibody (A-8) References:

1. Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.  |  Murrey, HE., et al. 2006. Proc Natl Acad Sci U S A. 103: 21-6. PMID: 16373512
2. Synapsin regulation of vesicle organization and functional pools.  |  Bykhovskaia, M. 2011. Semin Cell Dev Biol. 22: 387-92. PMID: 21827866
3. A liquid phase of synapsin and lipid vesicles.  |  Milovanovic, D., et al. 2018. Science. 361: 604-607. PMID: 29976799
4. Protonation states at different pH, conformational changes and impact of glycosylation in synapsin Ia.  |  Mir, S., et al. 2021. Phys Chem Chem Phys. 23: 16718-16729. PMID: 34318818
5. Temporal onset of synapsin I gene expression coincides with neuronal differentiation during the development of the nervous system.  |  Melloni, RH. and DeGennaro, LJ. 1994. J Comp Neurol. 342: 449-62. PMID: 8021345
6. Ca2+-dependent interaction with calmodulin is conserved in the synapsin family: identification of a high-affinity site.  |  Nicol, S., et al. 1997. Biochemistry. 36: 11487-95. PMID: 9298969
7. Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation.  |  Hosaka, M. and Südhof, TC. 1998. J Biol Chem. 273: 1425-9. PMID: 9430678
8. Synapsin I is structurally similar to ATP-utilizing enzymes.  |  Esser, L., et al. 1998. EMBO J. 17: 977-84. PMID: 9463376
9. A third member of the synapsin gene family.  |  Kao, HT., et al. 1998. Proc Natl Acad Sci U S A. 95: 4667-72. PMID: 9539796
10. Synapsin III, a novel synapsin with an unusual regulation by Ca2+.  |  Hosaka, M. and Südhof, TC. 1998. J Biol Chem. 273: 13371-4. PMID: 9593663
11. Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.  |  Südhof, TC., et al. 1989. Science. 245: 1474-80. PMID: 2506642
12. The structure of the human synapsin I gene and protein.  |  Südhof, TC. 1990. J Biol Chem. 265: 7849-52. PMID: 2110562

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Synapsin Ia/b Antibody (A-8) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-Synapsin Ia/b Antibody (A-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Synapsin Ia/b Antibody (A-8) Specifications

Alternate Product Name: Synapsin 1

Product Clone Name: A-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 2-29

Epitope Target: Synapsin Ia/b

Epitope Species: human

Product Reactivity/Detection: a broad range of synapsin family members

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for Synapsin Ia/b Antibody (A-8): P: Blocking Peptide