Syk Antibody (SYK-01): sc-51703
- Syk Antibody (SYK-01) is a mouse monoclonal IgG1, cited in 13 publications, provided at 100 µg/ml
- raised against recombinant fragment, corresponding to amino acids 5-360 of human Syk
- recommended for detection of Syk of mouse, rat and human origin by WB (non-reducing), IP and IF
- See Syk (4D10): sc-1240 for Syk antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Syk Antibody (SYK-01). This work is in progress.
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SEE ALSO...
Syk Antibody (SYK-01) is a mouse monoclonal IgG1 antibody that detects Syk in mouse, rat, and human samples through applications such as western blotting (non-reducing), immunoprecipitation, and immunofluorescence. Syk, or spleen tyrosine kinase, is a 635 amino acid protein characterized by one protein kinase domain and two SH2 domains, playing a crucial role in B cell signaling. Syk acts as a positive effector of B cell antigen receptor (CD79)-stimulated responses, facilitating calcium ion movement through two distinct phospho-regulated pathways. When unphosphorylated, Syk enables calcium ions to traverse a phosphoinositide 3-kinase-dependent pathway, while phosphorylation at Tyr 348 and Tyr 352 shifts transport to a phospholipase C γ-dependent pathway. This regulation of calcium movement is vital for various cellular processes, including differentiation, phagocytosis, proliferation, and B cell development. Notably, Syk expression is upregulated in T cell lymphoma, indicating potential involvement in tumorigenesis. Additionally, Syk exists in two isoforms, short and long, resulting from alternative splicing, which may have distinct functional implications in cellular signaling pathways. Anti-Syk antibody (SYK-01) is an essential tool for researchers investigating the complex roles of Syk in immune responses and cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Syk Antibody (SYK-01) | sc-51703 | 100 µg/ml | $322.00 |