SYF2 Antibody (B-11): sc-393109
- SYF2 Antibody (B-11) is a mouse monoclonal IgM κ SYF2 antibody provided at 200 µg/ml
- raised against amino acids 90-243 mapping at the C-terminus of SYF2 of human origin
- recommended for detection of SYF2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine
- TransCruz reagent for ChIP application (sc-393109 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SYF2 Antibody (B-11). This work is in progress.
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SEE ALSO...
SYF2 Antibody (B-11) is a mouse monoclonal IgM kappa antibody that detects SYF2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SYF2 (B-11) antibody is available as the non-conjugated form. SYF2 protein, also known as SYF2 homolog, RNA splicing factor, or CCNDBP1-interactor (p29), consists of 243 amino acids and is a member of the SYF2 family. SYF2 protein is predominantly localized in the nucleus, where SYF2 plays a crucial role in pre-mRNA splicing and cell cycle progression, acting as a potential regulator of DNA replication checkpoints. SYF2′s function is important in gene expression regulation, which is vital for maintaining cellular homeostasis and responding to cellular stress. SYF2 gene is located on human chromosome 1p36.11, a region associated with numerous genetic disorders and cancers, highlighting SYF2′s significance in both normal physiology and disease states. Understanding SYF2′s role in cellular processes can provide insights into SYF2′s potential as a therapeutic target in diseases linked to splicing dysregulation.
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SYF2 Antibody (B-11) References:
- Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. | Ben-Yehuda, S., et al. 2000. Genetics. 156: 1503-17. PMID: 11102353
- p29, a novel GCIP-interacting protein, localizes in the nucleus. | Chang, MS., et al. 2000. Biochem Biophys Res Commun. 279: 732-7. PMID: 11118353
- Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. | Dahan, O. and Kupiec, M. 2002. Nucleic Acids Res. 30: 4361-70. PMID: 12384582
- Genetic interactions with CLF1 identify additional pre-mRNA splicing factors and a link between activators of yeast vesicular transport and splicing. | Vincent, K., et al. 2003. Genetics. 164: 895-907. PMID: 12871902
- Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody. | McClintock, D., et al. 2006. Proc Natl Acad Sci U S A. 103: 2154-9. PMID: 16461887
- The DNA sequence and biological annotation of human chromosome 1. | Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
- Silencing of p29 affects DNA damage responses with UV irradiation. | Chu, PC., et al. 2006. Cancer Res. 66: 8484-91. PMID: 16951160
- Role of chromosome 1 pericentric heterochromatin (1q) in pathogenesis of myelodysplastic syndromes: report of 2 new cases. | Millington, K., et al. 2008. Exp Mol Pathol. 84: 189-93. PMID: 18339374
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SYF2 Antibody (B-11) | sc-393109 | 200 µg/ml | $316.00 | |||
SYF2 Antibody (B-11) X | sc-393109 X | 200 µg/0.1 ml | $316.00 |