SV40 T Ag Antibody (Pab 430): sc-53449
- SV40 T Ag Antibody (Pab 430) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- raised against SV40 transformed cells of SV40 origin
- recommended for detection of large T antigen of SV40 origin by WB and IP
- See SV40 T Ag (Pab 101): sc-147 for SV40 T Ag antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SV40 T Ag Antibody (Pab 430). This work is in progress.
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SV40 T Ag Antibody (Pab 430) is a mouse monoclonal IgG3 antibody that detects SV40 T Ag in SV40 by western blotting (WB) and immunoprecipitation (IP). SV40 T Ag plays a crucial role in the viral life cycle and is essential for the transformation of host cells, as SV40 T Ag interacts with key cellular proteins that regulate cell growth and division. Notably, SV40 T Ag binds to the retinoblastoma (Rb) protein, specifically targeting the "pocket" domain, which is also the binding site for the E2F transcription factor. This interaction leads to the inactivation of Rb, disrupting Rb′s ability to regulate the cell cycle and promoting uncontrolled cell proliferation. Additionally, SV40 T Ag′s ability to form complexes with other tumor suppressor proteins, such as p53, further underscores SV40 T Ag′s importance in oncogenic processes. Anti-SV40 T Ag antibody (Pab 430) serves as an invaluable tool for researchers studying the mechanisms of viral oncogenesis and the intricate pathways involved in cellular transformation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SV40 T Ag Antibody (Pab 430) | sc-53449 | 200 µg/ml | $322.00 |