SURF-1 Antibody (B-7): sc-365060

SURF-1 Antibody (B-7) is a mouse monoclonal IgM antibody that detects SURF-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SURF-1 plays a crucial role in the assembly of complex IV (cytochrome c oxidase) of the mitochondrial respiratory chain, which is essential for cellular respiration and energy production. Located in the inner mitochondrial membrane, proper functioning of SURF-1 is vital for maintaining mitochondrial integrity and energy metabolism. Mutations in the SURF-1 gene can lead to cytochrome c oxidase complex IV deficiency, resulting in severe conditions such as Leigh syndrome, characterized by rapid neurological decline and necrotic lesions in the brain. The implications of SURF-1 mutations extend beyond neurological disorders, as these mutations are also associated with significant deficits in muscle strength and motor performance, highlighting SURF-1′s importance in both the nervous and muscular systems. Morphological abnormalities in the heart, brain, and skeletal muscle are frequently observed in individuals with SURF-1 mutations, underscoring the critical role SURF-1 plays in overall cellular health and function. With detection capabilities across various species and applications, anti-SURF-1 antibody (B-7) serves as an invaluable tool for researchers studying mitochondrial function and related pathologies.

The preferred SURF-1 antibody is SURF-1 Antibody (H-7): sc-365159.