Sulfiredoxin Antibody (E-7): sc-166566

Sulfiredoxin Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects Sulfiredoxin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sulfiredoxin, also known as Sulfiredoxin-1 or chromosome 20 open reading frame 139 (C20orf139), plays a crucial role as a cytoplasmic antioxidant protein, primarily involved in the reduction of oxidative modifications that can lead to cellular damage. Sulfiredoxin is essential for regulating peroxiredoxins (PRXs), a family of proteins that mitigate oxidative stress by reducing hydroperoxides. Sulfiredoxin specifically reduces the conserved cysteine residue in PRXs from sulfinic to sulfenic acid, thereby enhancing their ability to participate in downstream signaling pathways involving transcription factors and kinases. Sulfiredoxin selectively interacts with PRDX1, PRDX2, PRDX3, and PRDX4, while showing no effect on PRDX5 or PRDX6, highlighting its specificity in cellular redox regulation. The widespread expression of Sulfiredoxin, particularly in lung, spleen, kidney, and thymus tissues, underscores its importance in maintaining cellular homeostasis and responding to oxidative stress. Anti-Sulfiredoxin antibody (E-7) serves as an invaluable tool for researchers investigating the mechanisms of oxidative stress and the role of peroxiredoxins in various biological processes.

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Sulfiredoxin Antibody (E-7) References:

1. Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin.  |  Soriano, FX., et al. 2009. Mol Cells. 27: 279-82. PMID: 19326073
2. Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression.  |  Jeong, W., et al. 2012. Free Radic Biol Med. 53: 447-56. PMID: 22634055
3. Role of sulfiredoxin in systemic diseases influenced by oxidative stress.  |  Ramesh, A., et al. 2014. Redox Biol. 2: 1023-8. PMID: 25460739
4. The sulfiredoxin-peroxiredoxin (Srx-Prx) axis in cell signal transduction and cancer development.  |  Mishra, M., et al. 2015. Cancer Lett. 366: 150-9. PMID: 26170166
5. Circadian Oscillation of Sulfiredoxin in the Mitochondria.  |  Kil, IS., et al. 2015. Mol Cell. 59: 651-63. PMID: 26236015
6. Sulfiredoxin-1 attenuates injury and inflammation in acute pancreatitis through the ROS/ER stress/Cathepsin B axis.  |  He, J., et al. 2021. Cell Death Dis. 12: 626. PMID: 34140464
7. p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3.  |  Rius-Pérez, S., et al. 2022. Redox Biol. 56: 102423. PMID: 36029648
8. Sulfiredoxin-1 accelerates erastin-induced ferroptosis in HT-22 hippocampal neurons by driving heme Oxygenase-1 activation.  |  Guo, S., et al. 2024. Free Radic Biol Med. 223: 430-442. PMID: 39159887
9. Sulfiredoxin 1 ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the Sirt1/NLRP3 pathway.  |  Zhang, Z., et al. 2024. Int Immunopharmacol. 141: 113010. PMID: 39182271
10. The de-sulfinylation enzyme sulfiredoxin-1 attenuates hepatic stellate cell activation and liver fibrosis by modulating the PTPN12-NLRP3 axis.  |  Kim, JW., et al. 2024. Hepatology.. PMID: 39446334

The preferred Sulfiredoxin antibody is Sulfiredoxin Antibody (E-2): sc-166747.