Steroid sulfatase/STS Antibody (A-6): sc-518238

STS Antibody (A-6) is a mouse monoclonal IgM kappa light chain antibody specific for an epitope mapping between amino acids 514-531 of STS of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-STS antibody (A-6) is available as the non-conjugated form. Steroid sulfatase (STS) is an enzymatic homodimer located in the endoplasmic reticulum membrane, where STS plays a crucial role in converting sulfated steroid precursors into bioactive estrogens, particularly during pregnancy. This enzymatic activity maintains hormonal balance and supports reproductive functions. Notably, retinoids stimulate STS activity, thereby influencing estrogen levels. Mutations in the STS gene are linked to X-linked ichthyosis, a diskeratinization disorder characterized by prominent scales on the skin. Elevated STS expression has been observed in human breast carcinoma and acute promyelocytic leukemia, indicating STS′s role in tumor growth and making STS a potential therapeutic target for estrogen- and androgen-dependent diseases. STS monoclonal antibody (A-6) serves as an essential tool for researchers investigating STS implications in health and disease.

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Steroid sulfatase/STS Antibody (A-6) References:

1. Distribution of estrone sulfatase in rat brain determined by in vitro autoradiography with 16alpha-[18F]fluoroestradiol-3,17beta-disulfamate.  |  Rodig, H., et al. 2002. Appl Radiat Isot. 56: 773-80. PMID: 12102332
2. Structure of human estrone sulfatase suggests functional roles of membrane association.  |  Hernandez-Guzman, FG., et al. 2003. J Biol Chem. 278: 22989-97. PMID: 12657638
3. Confocal fluorescence detection expanded to UV excitation: the first continuous fluorimetric assay of human steroid sulfatase in nanoliter volume.  |  Billich, A., et al. 2004. Assay Drug Dev Technol. 2: 21-30. PMID: 15090207
4. 2-phenylindole sulfamates: inhibitors of steroid sulfatase with antiproliferative activity in MCF-7 breast cancer cells.  |  Walter, G., et al. 2004. J Steroid Biochem Mol Biol. 88: 409-20. PMID: 15145451
5. Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma.  |  Utsunomiya, H., et al. 2004. Clin Cancer Res. 10: 5850-6. PMID: 15355916
6. Steroid sulfatase: molecular biology, regulation, and inhibition.  |  Reed, MJ., et al. 2005. Endocr Rev. 26: 171-202. PMID: 15561802
7. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.  |  Hughes, PJ., et al. 2006. J Cell Biochem. 97: 327-50. PMID: 16178010
8. Transgenic Overexpression of Steroid Sulfatase Alleviates Cholestasis.  |  Jiang, M., et al. 2017. Liver Res. 1: 63-69. PMID: 29130021
9. In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics.  |  McNamara, KM., et al. 2018. Br J Cancer. 118: 1208-1216. PMID: 29563635
10. Steroid sulfatase inhibitors: the current landscape.  |  Anbar, HS., et al. 2021. Expert Opin Ther Pat. 31: 453-472. PMID: 33783295
11. Aromatase and steroid sulfatase from human placenta.  |  Ghosh, D. 2023. Methods Enzymol. 689: 67-86. PMID: 37802583
12. Steroid sulfatase and sulfotransferases in the estrogen and androgen action of gynecological cancers: current status and perspectives.  |  Rižner, TL. and Gjorgoska, M. 2024. Essays Biochem. 68: 411-422. PMID: 38994718

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Steroid sulfatase/STS Antibody (A-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Steroid sulfatase/STS Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Steroid sulfatase/STS Antibody (A-6) Specifications

Alternate Product Name: STS

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 514-531

Epitope Target: STS

Epitope Species: human

Product Reactivity/Detection: STS

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Steroid sulfatase/STS Antibody (A-6): N/A