striatin Antibody (6): sc-136084

Striatin Antibody (6) is a mouse monoclonal IgG2b antibody that detects striatin protein of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-striatin antibody (6) is available as a non-conjugated monoclonal isotype antibody. Striatin, also known as SG2NA, is a crucial protein that plays a significant role in neuronal function and development. Striatin is primarily located in the somatodendritic compartment of neurons, including dendritic spines, where striatin is essential for maintaining neuronal polarity and facilitating synaptic signaling. Proper localization of striatin ensures signaling pathways are correctly activated in response to calcium levels, which is critical for processes such as synaptic plasticity and memory formation. Dysregulation of striatin expression can lead to impaired dendritic growth and altered locomotor activity, highlighting striatin′s importance in neuronal health and function. Striatin interacts with other proteins within the striatin family, such as zinedin and SG2NA, which share similar structural features and protein-protein interaction domains, further emphasizing the interconnectedness of these proteins in cellular signaling pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

striatin Antibody (6) References:

1. Down-regulation of striatin, a neuronal calmodulin-binding protein, impairs rat locomotor activity.  |  Bartoli, M., et al. 1999. J Neurobiol. 40: 234-43. PMID: 10413453
2. Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain.  |  Castets, F., et al. 2000. J Biol Chem. 275: 19970-7. PMID: 10748158
3. Molecular cloning and characterization of phocein, a protein found from the Golgi complex to dendritic spines.  |  Baillat, G., et al. 2001. Mol Biol Cell. 12: 663-73. PMID: 11251078
4. A WD40 repeat protein regulates fungal cell differentiation and can be replaced functionally by the mammalian homologue striatin.  |  Pöggeler, S. and Kück, U. 2004. Eukaryot Cell. 3: 232-40. PMID: 14871953
5. Immunogold localization of phocein in dendritic spines.  |  Haeberlé, AM., et al. 2006. J Comp Neurol. 495: 336-50. PMID: 16440294
6. Targeting of proteins of the striatin family to dendritic spines: role of the coiled-coil domain.  |  Gaillard, S., et al. 2006. Traffic. 7: 74-84. PMID: 16445688
7. A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons.  |  Castets, F., et al. 1996. J Cell Biol. 134: 1051-62. PMID: 8769426
8. Relationships between striatin-containing neurons and cortical or thalamic afferent fibres in the rat striatum. An ultrastructural study by dual labelling.  |  Kachidian, P., et al. 1998. Neuroscience. 85: 111-22. PMID: 9607707
9. Distribution of striatin, a newly identified calmodulin-binding protein in the rat brain: an in situ hybridization and immunocytochemical study.  |  Salin, P., et al. 1998. J Comp Neurol. 397: 41-59. PMID: 9671278

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-striatin Antibody (6) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-striatin Antibody (6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

striatin Antibody (6) Specifications

Alternate Product Name: striatin

Product Clone Name: 6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids: 450-600

Epitope Target: striatin

Epitope Species: rat

Product Reactivity/Detection: striatin

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for striatin Antibody (6): N/A