Streptavidin Antibody (3521): sc-58198

Streptavidin Antibody (3521) is a mouse monoclonal IgG1 antibody that detects Streptavidin in various species by western blotting (WB). Streptavidin is a tetrameric protein derived from Streptomyces avidinii, known for its exceptional ability to bind biotin with one of the strongest noncovalent interactions in nature. Each monomer of Streptavidin can bind a single molecule of biotin, making Streptavidin an invaluable tool in molecular biology and biochemistry. The significance of this strong Streptavidin-Biotin interaction lies in applications for linking biomolecules, which is crucial for various experimental techniques, including protein purification and diagnostic assay development. The ability to connect different chemicals onto surfaces or link molecules such as radioisotopes and monoclonal antibodies enhances Streptavidin′s versatility in laboratory settings. Streptavidin serves as a fundamental component in many immunochemical protocols and diagnostic kits, facilitating advancements in research and clinical diagnostics.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Streptavidin Antibody (3521) References:

1. Streptavidin-binding and -dimerizing ligands discovered by phage display, topochemistry, and structure-based design.  |  Katz, BA. 1999. Biomol Eng. 16: 57-65. PMID: 10796985
2. Monovalent streptavidin that senses oligonucleotides.  |  Taylor, SK., et al. 2013. Angew Chem Int Ed Engl. 52: 5509-12. PMID: 23606329
3. Optimized Streptavidin for Fluorescent Labeling of Biotinylated Targets.  |  Hytönen, VP. 2017. Cell Chem Biol. 24: 921-922. PMID: 28820961
4. Streptavidin Homologues for Applications on Solid Surfaces at High Temperatures.  |  Schmidt, C., et al. 2020. Langmuir. 36: 628-636. PMID: 31895565
5. Cooperative allostery and structural dynamics of streptavidin at cryogenic- and ambient-temperature.  |  Ayan, E., et al. 2022. Commun Biol. 5: 73. PMID: 35058563
6. Cytosolic Protein Delivery Using Modular Biotin-Streptavidin Assembly of Nanocomposites.  |  Luther, DC., et al. 2022. ACS Nano. 16: 7323-7330. PMID: 35435664
7. Mirror-image streptavidin with specific binding to L-biotin, the unnatural enantiomer.  |  Suganuma, M., et al. 2022. Sci Rep. 12: 9568. PMID: 35688934
8. Immobilization of biotinylated antibodies through streptavidin binding aptamer.  |  Brambilla, D., et al. 2023. Talanta. 265: 124847. PMID: 37390669
9. Manganese Transfer Hydrogenases Based on the Biotin-Streptavidin Technology.  |  Wang, W., et al. 2023. Angew Chem Int Ed Engl. 62: e202311896. PMID: 37671593
10. Tumor Pre-Targeting System Using Streptavidin-Expressing Bacteria.  |  Kwon, SY., et al. 2024. Mol Imaging Biol. 26: 593-602. PMID: 38814379

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Streptavidin Antibody (3521) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Streptavidin Antibody (3521) Specifications

Alternate Product Name: Streptavidin

Product Clone Name: 3521

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Streptavidin

Epitope Species: Streptomyces avidinii

Product Reactivity/Detection: Streptavidin

Species Reactivity/Detection:

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Streptavidin Antibody (3521): N/A