STI1 Antibody (E-7): sc-390224

STI1 Antibody (E-7) is a mouse monoclonal IgG2a antibody that detects stress-induced-phosphoprotein 1 (STI1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). STI1 plays a crucial role as a co-chaperone for heat shock proteins HSP70 and HSP90, which are essential for protein folding and protection under stress conditions. STI1′s ability to exist as either a monomer or a dimer is significant, as this conformational flexibility allows for effective organization and facilitation of HSP70 and HSP90 function. By acting as a scaffold, STI1 aids in recruiting client proteins to the relaxed, ADP-bound conformation of HSP90, thereby suppressing ATP turnover during the loading phase and ensuring proper protein folding and function. STI1′s importance in maintaining cellular protein homeostasis under stress highlights potential therapeutic interventions in diseases associated with protein misfolding and aggregation. anti-STI1 antibody (E-7) serves as an invaluable tool for researchers studying cellular stress responses and protein interactions.

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STI1 Antibody (E-7) References:

1. The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically.  |  Abbas-Terki, T., et al. 2002. Biol Chem. 383: 1335-42. PMID: 12437126
2. Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase.  |  Lee, P., et al. 2004. Mol Biol Cell. 15: 1785-92. PMID: 14742721
3. PrP cooperates with STI1 to regulate SOD activity in PrP-deficient neuronal cell line.  |  Sakudo, A., et al. 2005. Biochem Biophys Res Commun. 328: 14-9. PMID: 15670743
4. STI1 promotes glioma proliferation through MAPK and PI3K pathways.  |  Erlich, RB., et al. 2007. Glia. 55: 1690-8. PMID: 17886292
5. Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1.  |  Romano, SA., et al. 2009. FASEB J. 23: 4308-16. PMID: 19703931
6. The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins.  |  Wolfe, KJ., et al. 2013. Mol Biol Cell. 24: 3588-602. PMID: 24109600
7. STI1 antagonizes cytoskeleton collapse mediated by small GTPase Rnd1 and regulates neurite growth.  |  de Souza, LE., et al. 2014. Exp Cell Res. 324: 84-91. PMID: 24690281
8. Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules.  |  Röhl, A., et al. 2015. Nat Commun. 6: 6655. PMID: 25851214
9. The Hsp90 Co-chaperones Sti1, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles.  |  Gu, X., et al. 2016. Front Microbiol. 7: 1571. PMID: 27761133
10. Loss of STI1-mediated neuronal survival and differentiation in disease-associated mutations of prion protein.  |  Landemberger, MC., et al. 2018. J Neurochem. 145: 409-416. PMID: 29337365

The preferred STI1 antibody is STI1 Antibody (D-6): sc-390203.