STI1 Antibody (28): sc-136082
- STI1 Antibody (28) is a mouse monoclonal IgG1, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against amino acids 22-143 of STI1 of human origin
- recommended for detection of STI1 of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for STI1 Antibody (28). This work is in progress.
QUICK LINKS
SEE ALSO...
STI1 Antibody (28) is a mouse monoclonal IgG1 antibody that detects stress-induced-phosphoprotein 1 (STI1) in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). STI1 plays a crucial role as a co-chaperone for the heat shock proteins HSP70 and HSP90, which are essential for protein folding and protection under stress conditions. STI1′s ability to exist as either a monomer or a dimer is significant, as this conformational flexibility allows STI1 to effectively organize and facilitate the recruitment of client proteins to HSP90. This recruitment is vital because HSP90 functions as an ATPase, and HSP90 activity is dependent on the proper conformation and loading of client proteins. By acting as a scaffold, STI1 helps maintain the relaxed, ADP-bound state of HSP90, thereby suppressing ATP turnover during the loading phase and ensuring that HSP90 can perform essential functions in cellular stress responses. Anti-STI1 antibody (28) is an invaluable tool for researchers studying the intricate mechanisms of protein homeostasis and stress response pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
STI1 Antibody (28) References:
- Sti1 is a novel activator of the Ssa proteins. | Wegele, H., et al. 2003. J Biol Chem. 278: 25970-6. PMID: 12716905
- Hop/STI1 modulates retinal proliferation and cell death independent of PrPC. | Arruda-Carvalho, M., et al. 2007. Biochem Biophys Res Commun. 361: 474-80. PMID: 17651690
- Co-variation of STI1 and WDR36/UTP21 alters cell proliferation in a glaucoma model. | Footz, T., et al. 2011. Mol Vis. 17: 1957-69. PMID: 21850170
- Dynamics of the regulation of Hsp90 by the co-chaperone Sti1. | Lee, CT., et al. 2012. EMBO J. 31: 1518-28. PMID: 22354036
- Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co-chaperone STI1. | Lackie, RE., et al. 2020. J Neurochem. 153: 727-758. PMID: 31562773
- The STI1-domain is a flexible alpha-helical fold with a hydrophobic groove. | Fry, MY., et al. 2021. Protein Sci. 30: 882-898. PMID: 33620121
- Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity. | Lin, LT., et al. 2021. FASEB J. 35: e21594. PMID: 33908654
- The Hsp70-Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration. | Bhattacharya, K. and Picard, D. 2021. Cell Mol Life Sci. 78: 7257-7273. PMID: 34677645
- Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo. | Lackie, RE., et al. 2022. Acta Neuropathol. 144: 881-910. PMID: 36121476
- Stress-inducible phosphoprotein 1 (Sti1/Stip1/Hop) sequesters misfolded proteins during stress. | Rutledge, BS., et al. 2024. FEBS J.. PMID: 39739753
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STI1 Antibody (28) | sc-136082 | 50 µg/0.5 ml | $322.00 |