StARD13 Antibody (H-10): sc-377054
- StARD13 Antibody (H-10) is a mouse monoclonal IgG1 κ StARD13 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-60 mapping at the N-terminus of StARD13 of human origin
- StARD13 Antibody (H-10) is recommended for detection of StARD13 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-StARD13 Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for StARD13 Antibody (H-10) for WB applications. These reagents are now offered in bundles with StARD13 Antibody (H-10) (see ordering information below).
QUICK LINKS
StARD13 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects StARD13 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). StARD13 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. StARD13, also known as deleted in liver cancer protein 2 (DLC2) or GT650, is a member of the steroidogenic acute regulatory protein-related lipid transfer (START) domain family, which consists of fifteen proteins that play crucial roles in lipid metabolism and transport. StARD13 functions as a RhoGAP protein that interacts with Rho A and Cdc42, and contains a RhoGAP domain, a sterile alpha motif (SAM) domain, and a START domain. StARD13 localizes to the mitochondrion and cytoplasmic speckles, where StARD13 associates closely with lipid droplets, indicating a potential role in mitochondrial lipid transport. This localization suggests involvement in regulating lipid homeostasis within cells. StARD13 shows ubiquitous expression but is frequently deleted in hepatocellular and breast cancer cells, highlighting a function as a tumor suppressor.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
StARD13 Antibody (H-10) References:
- Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. | Ching, YP., et al. 2003. J Biol Chem. 278: 10824-30. PMID: 12531887
- Identification and characterization of ARHGAP27 gene in silico. | Katoh, Y. and Katoh, M. 2004. Int J Mol Med. 14: 943-7. PMID: 15492870
- Mitochondrial targeting of growth suppressor protein DLC2 through the START domain. | Ng, DC., et al. 2006. FEBS Lett. 580: 191-8. PMID: 16364308
- Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors. | Ullmannova, V. and Popescu, NC. 2006. Int J Oncol. 29: 1127-32. PMID: 17016643
- Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2. | Li, H., et al. 2007. Proteins. 67: 1154-66. PMID: 17380510
- The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundle. | Kwan, JJ. and Donaldson, LW. 2007. BMC Struct Biol. 7: 34. PMID: 17519008
- START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology. | Kawai, K., et al. 2007. Biochem Biophys Res Commun. 364: 783-9. PMID: 17976533
- StARD13(Dlc-2) RhoGap mediates ceramide activation of phosphatidylglycerolphosphate synthase and drug response in Chinese hamster ovary cells. | Hatch, GM., et al. 2008. Mol Biol Cell. 19: 1083-92. PMID: 18162584
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
StARD13 Antibody (H-10) | sc-377054 | 200 µg/ml | $316.00 | |||
StARD13 Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-527577 | 200 µg Ab; 10 µg BP | $354.00 | |||
StARD13 Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-532950 | 200 µg Ab; 20 µg BP | $354.00 | |||
StARD13 Antibody (H-10) AC | sc-377054 AC | 500 µg/ml, 25% agarose | $416.00 | |||
StARD13 Antibody (H-10) HRP | sc-377054 HRP | 200 µg/ml | $316.00 | |||
StARD13 Antibody (H-10) FITC | sc-377054 FITC | 200 µg/ml | $330.00 | |||
StARD13 Antibody (H-10) PE | sc-377054 PE | 200 µg/ml | $343.00 | |||
StARD13 Antibody (H-10) Alexa Fluor® 488 | sc-377054 AF488 | 200 µg/ml | $357.00 | |||
StARD13 Antibody (H-10) Alexa Fluor® 546 | sc-377054 AF546 | 200 µg/ml | $357.00 | |||
StARD13 Antibody (H-10) Alexa Fluor® 594 | sc-377054 AF594 | 200 µg/ml | $357.00 | |||
StARD13 Antibody (H-10) Alexa Fluor® 647 | sc-377054 AF647 | 200 µg/ml | $357.00 | |||
StARD13 Antibody (H-10) Alexa Fluor® 680 | sc-377054 AF680 | 200 µg/ml | $357.00 | |||
StARD13 Antibody (H-10) Alexa Fluor® 790 | sc-377054 AF790 | 200 µg/ml | $357.00 |