ST2 Antibody (D14L): sc-74297
- ST2 Antibody (D14L) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against an extracellular domain of ST2 of human origin
- recommended for detection of ST2 of human origin by WB
- also provided azide-free for neutralization, sc-74297 L, 100 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ST2 Antibody (D14L). This work is in progress.
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ST2 Antibody (D14L) is a mouse monoclonal IgG1 antibody that detects ST2 in human samples through western blotting (WB). ST2 is an orphan receptor belonging to the IL-1 receptor family, notable for its unique expression pattern, primarily on the surface of T helper cell type 2 (Th2) cells, while being absent in Th1 cells. The gene encoding human ST2 is located on chromosome 2q12.1 and is regulated by two distinct promoters, allowing for expression in different cell types, including hematopoietic cells and fibroblasts. ST2 undergoes alternative splicing to generate three distinct isoforms: the secreted soluble form (ST2S), predominantly found in fibroblasts; the membrane-bound form (ST2L), expressed in hematopoietic cells; and ST2V, which is localized on the plasma membrane and expressed in the stomach, small intestine, and colon. The functional significance of ST2 lies in immunoregulatory properties, which suggest a potential role in modulating inflammatory responses, making ST2 a promising target for therapeutic interventions aimed at treating inflammatory diseases. Anti-ST2 antibody (D14L) serves as an essential tool for researchers investigating ST2′s role in health and disease.
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ST2 Antibody (D14L) References:
- The ST2/IL-33 Axis in Immune Cells during Inflammatory Diseases. | Griesenauer, B. and Paczesny, S. 2017. Front Immunol. 8: 475. PMID: 28484466
- Regulatory Mechanisms of IL-33-ST2-Mediated Allergic Inflammation. | Takatori, H., et al. 2018. Front Immunol. 9: 2004. PMID: 30233590
- ST2 and Prognosis in Chronic Heart Failure. | Richards, AM. 2018. J Am Coll Cardiol. 72: 2321-2323. PMID: 30384888
- ST2/IL-33 signaling in cardiac fibrosis. | Vianello, E., et al. 2019. Int J Biochem Cell Biol. 116: 105619. PMID: 31561019
- ST2 Signaling in the Tumor Microenvironment. | Chang, CP., et al. 2020. Adv Exp Med Biol. 1240: 83-93. PMID: 32060890
- Setd2 supports GATA3+ST2+ thymic-derived Treg cells and suppresses intestinal inflammation. | Ding, Z., et al. 2022. Nat Commun. 13: 7468. PMID: 36463230
- ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses. | Topczewska, PM., et al. 2023. Front Immunol. 14: 1130933. PMID: 37063913
- IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity. | Wang, Z., et al. 2023. Cell Commun Signal. 21: 80. PMID: 37081450
- Soluble ST2 in Heart Failure: A Clinical Role beyond B-Type Natriuretic Peptide. | Riccardi, M., et al. 2023. J Cardiovasc Dev Dis. 10: PMID: 37998526
- Interleukin-33/ST2 axis involvement in atrial remodeling and arrhythmogenesis. | Cheng, TY., et al. 2024. Transl Res. 268: 1-12. PMID: 38244770
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ST2 Antibody (D14L) | sc-74297 | 100 µg/ml | $316.00 | |||
ST2 Antibody (D14L) L | sc-74297 L | 100 µg/0.1 ml | $316.00 |